QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, April 19, 2006, 26(16):4166-4177; doi:10.1523/JNEUROSCI.0176-06.2006

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (68) Citing Articles via Google Scholar Google Scholar Articles by Bender, V. A. Articles by Feldman, D. E. Search for Related Content PubMed PubMed Citation Articles by Bender, V. A. Articles by Feldman, D. E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Two Coincidence Detectors for Spike Timing-Dependent Plasticity in Somatosensory Cortex

Vanessa A. Bender,² Kevin J. Bender,¹ Daniel J. Brasier,² and Daniel E. Feldman^1,2

¹Division of Biological Sciences and ²Neurosciences Program, University of California, San Diego, La Jolla, California 92093-0357

Correspondence should be addressed to Daniel E. Feldman, Division of Biology, University of California, San Diego, 3228 Pacific Hall, 0357, 9500 Gilman Drive, La Jolla, CA 92093-0357. Email: dfeldman{at}ucsd.edu

Many cortical synapses exhibit spike timing-dependent plasticity (STDP) in which the precise timing of presynaptic and postsynaptic spikes induces synaptic strengthening [long-term potentiation (LTP)] or weakening [long-term depression (LTD)]. Standard models posit a single, postsynaptic, NMDA receptor-based coincidence detector for LTP and LTD components of STDP. We show instead that STDP at layer 4 to layer 2/3 synapses in somatosensory (S1) cortex involves separate calcium sources and coincidence detection mechanisms for LTP and LTD. LTP showed classical NMDA receptor dependence. LTD was independent of postsynaptic NMDA receptors and instead required group I metabotropic glutamate receptors and calcium from voltage-sensitive channels and IP₃ receptor-gated stores. Downstream of postsynaptic calcium, LTD required retrograde endocannabinoid signaling, leading to presynaptic LTD expression, and also required activation of apparently presynaptic NMDA receptors. These LTP and LTD mechanisms detected firing coincidence on 25 and 125 ms time scales, respectively, and combined to implement the overall STDP rule. These findings indicate that STDP is not a unitary process and suggest that endocannabinoid-dependent LTD may be relevant to cortical map plasticity.

Key words: LTP; LTD; synaptic plasticity; endocannabinoid; barrel; metabotropic glutamate receptor

---

Received Jan. 13, 2006; revised March 6, 2006; accepted March 11, 2006.

Correspondence should be addressed to Daniel E. Feldman, Division of Biology, University of California, San Diego, 3228 Pacific Hall, 0357, 9500 Gilman Drive, La Jolla, CA 92093-0357. Email: dfeldman{at}ucsd.edu

This article has been cited by other articles:

				M. Zilberter, C. Holmgren, I. Shemer, G. Silberberg, S. Grillner, T. Harkany, and Y. Zilberter Input Specificity and Dependence of Spike Timing-Dependent Plasticity on Preceding Postsynaptic Activity at Unitary Connections between Neocortical Layer 2/3 Pyramidal Cells Cereb Cortex, October 1, 2009; 19(10): 2308 - 2320. [Abstract] [Full Text] [PDF]

				N. Holbro, A. Grunditz, and T. G. Oertner Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses PNAS, September 1, 2009; 106(35): 15055 - 15060. [Abstract] [Full Text] [PDF]

				J.-C. Zhang, P.-M. Lau, and G.-Q. Bi Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses PNAS, August 4, 2009; 106(31): 13028 - 13033. [Abstract] [Full Text] [PDF]

				M. L. Harper, T. Rasolkhani-Kalhorn, and J. F. Drozd On the Neural Basis of EMDR Therapy: Insights From qEEG Studies Traumatology, June 1, 2009; 15(2): 81 - 95. [Abstract] [PDF]

				M. A. Penzo and J. L. Pena Endocannabinoid-Mediated Long-Term Depression in the Avian Midbrain Expressed Presynaptically and Postsynaptically J. Neurosci., April 1, 2009; 29(13): 4131 - 4139. [Abstract] [Full Text] [PDF]

				M. Kano, T. Ohno-Shosaku, Y. Hashimotodani, M. Uchigashima, and M. Watanabe Endocannabinoid-Mediated Control of Synaptic Transmission Physiol Rev, January 1, 2009; 89(1): 309 - 380. [Abstract] [Full Text] [PDF]

				E. J. Galvan, E. Calixto, and G. Barrionuevo Bidirectional Hebbian Plasticity at Hippocampal Mossy Fiber Synapses on CA3 Interneurons J. Neurosci., December 24, 2008; 28(52): 14042 - 14055. [Abstract] [Full Text] [PDF]

				R. Corlew, D. J. Brasier, D. E. Feldman, and B. D. Philpot Presynaptic NMDA Receptors: Newly Appreciated Roles in Cortical Synaptic Function and Plasticity Neuroscientist, December 1, 2008; 14(6): 609 - 625. [Abstract] [PDF]

				J. C. Madara and E. S. Levine Presynaptic and Postsynaptic NMDA Receptors Mediate Distinct Effects of Brain-Derived Neurotrophic Factor on Synaptic Transmission J Neurophysiol, December 1, 2008; 100(6): 3175 - 3184. [Abstract] [Full Text] [PDF]

				J. R. Pugh and I. M. Raman Mechanisms of Potentiation of Mossy Fiber EPSCs in the Cerebellar Nuclei by Coincident Synaptic Excitation and Inhibition J. Neurosci., October 15, 2008; 28(42): 10549 - 10560. [Abstract] [Full Text] [PDF]

				J. Yang, S. E. L. Chamberlain, G. L. Woodhall, and R. S. G. Jones Mobility of NMDA autoreceptors but not postsynaptic receptors at glutamate synapses in the rat entorhinal cortex J. Physiol., October 15, 2008; 586(20): 4905 - 4924. [Abstract] [Full Text] [PDF]

				B. D. Heifets, V. Chevaleyre, and P. E. Castillo Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin PNAS, July 22, 2008; 105(29): 10250 - 10255. [Abstract] [Full Text] [PDF]

				Y. Huang, H. Yasuda, A. Sarihi, and T. Tsumoto Roles of Endocannabinoids in Heterosynaptic Long-Term Depression of Excitatory Synaptic Transmission in Visual Cortex of Young Mice J. Neurosci., July 9, 2008; 28(28): 7074 - 7083. [Abstract] [Full Text] [PDF]

				P. Luu and R. C. Malenka Spike Timing-Dependent Long-Term Potentiation in Ventral Tegmental Area Dopamine Cells Requires PKC J Neurophysiol, July 1, 2008; 100(1): 533 - 538. [Abstract] [Full Text] [PDF]

				I. Bureau, G. M. G. Shepherd, and K. Svoboda Circuit and Plasticity Defects in the Developing Somatosensory Cortex of Fmr1 Knock-Out Mice J. Neurosci., May 14, 2008; 28(20): 5178 - 5188. [Abstract] [Full Text] [PDF]

				P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]

				H. Urakubo, M. Honda, R. C. Froemke, and S. Kuroda Requirement of an Allosteric Kinetics of NMDA Receptors for Spike Timing-Dependent Plasticity J. Neurosci., March 26, 2008; 28(13): 3310 - 3323. [Abstract] [Full Text] [PDF]

				K. A. Pelkey and C. J. McBain Target-cell-dependent plasticity within the mossy fibre-CA3 circuit reveals compartmentalized regulation of presynaptic function at divergent release sites J. Physiol., March 15, 2008; 586(6): 1495 - 1502. [Abstract] [Full Text] [PDF]

				V. Pawlak and J. N. D. Kerr Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity J. Neurosci., March 5, 2008; 28(10): 2435 - 2446. [Abstract] [Full Text] [PDF]

				D. J. Brasier and D. E. Feldman Synapse-Specific Expression of Functional Presynaptic NMDA Receptors in Rat Somatosensory Cortex J. Neurosci., February 27, 2008; 28(9): 2199 - 2211. [Abstract] [Full Text] [PDF]

				H. Yasuda, Y. Huang, and T. Tsumoto Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus PNAS, February 26, 2008; 105(8): 3106 - 3111. [Abstract] [Full Text] [PDF]

				R. L. Clem, T. Celikel, and A. L. Barth Ongoing in Vivo Experience Triggers Synaptic Metaplasticity in the Neocortex Science, January 4, 2008; 319(5859): 101 - 104. [Abstract] [Full Text] [PDF]

				L. Adermark and D. M. Lovinger Retrograde endocannabinoid signaling at striatal synapses requires a regulated postsynaptic release step PNAS, December 18, 2007; 104(51): 20564 - 20569. [Abstract] [Full Text] [PDF]

				M. A. Farries and A. L. Fairhall Reinforcement Learning With Modulated Spike Timing Dependent Synaptic Plasticity J Neurophysiol, December 1, 2007; 98(6): 3648 - 3665. [Abstract] [Full Text] [PDF]

				Y. Hashimotodani, T. Ohno-Shosaku, M. Watanabe, and M. Kano Roles of phospholipase Cbeta and NMDA receptor in activity-dependent endocannabinoid release J. Physiol., October 15, 2007; 584(2): 373 - 380. [Abstract] [Full Text] [PDF]

				R. Corlew, Y. Wang, H. Ghermazien, A. Erisir, and B. D. Philpot Developmental Switch in the Contribution of Presynaptic and Postsynaptic NMDA Receptors to Long-Term Depression J. Neurosci., September 12, 2007; 27(37): 9835 - 9845. [Abstract] [Full Text] [PDF]

				J.-t. Lu, C.-y. Li, J.-P. Zhao, M.-m. Poo, and X.-h. Zhang Spike-Timing-Dependent Plasticity of Neocortical Excitatory Synapses on Inhibitory Interneurons Depends on Target Cell Type J. Neurosci., September 5, 2007; 27(36): 9711 - 9720. [Abstract] [Full Text] [PDF]

				E. L. Hill, T. Gallopin, I. Ferezou, B. Cauli, J. Rossier, P. Schweitzer, and B. Lambolez Functional CB1 Receptors Are Broadly Expressed in Neocortical GABAergic and Glutamatergic Neurons J Neurophysiol, April 1, 2007; 97(4): 2580 - 2589. [Abstract] [Full Text] [PDF]

				R. C. Gerkin, P.-M. Lau, D. W. Nauen, Y. T. Wang, and G.-Q. Bi Modular Competition Driven by NMDA Receptor Subtypes in Spike-Timing-Dependent Plasticity J Neurophysiol, April 1, 2007; 97(4): 2851 - 2862. [Abstract] [Full Text] [PDF]

				N. R. Hardingham, G. E. Hardingham, K. D. Fox, and J. J. B. Jack Presynaptic Efficacy Directs Normalization of Synaptic Strength in Layer 2/3 Rat Neocortex After Paired Activity J Neurophysiol, April 1, 2007; 97(4): 2965 - 2975. [Abstract] [Full Text] [PDF]

				R. A. Crozier, Y. Wang, C.-H. Liu, and M. F. Bear Deprivation-induced synaptic depression by distinct mechanisms in different layers of mouse visual cortex PNAS, January 23, 2007; 104(4): 1383 - 1388. [Abstract] [Full Text] [PDF]

				Y. Cai, J. P. Gavornik, L. N. Cooper, L. C. Yeung, and H. Z. Shouval Effect of Stochastic Synaptic and Dendritic Dynamics on Synaptic Plasticity in Visual Cortex and Hippocampus J Neurophysiol, January 1, 2007; 97(1): 375 - 386. [Abstract] [Full Text] [PDF]

				T. Nevian and B. Sakmann Spine Ca2+ Signaling in Spike-Timing-Dependent Plasticity J. Neurosci., October 25, 2006; 26(43): 11001 - 11013. [Abstract] [Full Text] [PDF]

				N. S. Desai, T. M. Casimiro, S. M. Gruber, and P. W. Vanderklish Early Postnatal Plasticity in Neocortex of Fmr1 Knockout Mice J Neurophysiol, October 1, 2006; 96(4): 1734 - 1745. [Abstract] [Full Text] [PDF]

				K. J. Bender, C. B. Allen, V. A. Bender, and D. E. Feldman Synaptic basis for whisker deprivation-induced synaptic depression in rat somatosensory cortex. J. Neurosci., April 19, 2006; 26(16): 4155 - 4165. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help