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Erratum for Hammond et al., J. Neurosci. 26 (6) 1844-1853.
The Journal of Neuroscience, April 26, 2006, 26(17):4714

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Erratum
Correction for Hammond et al., Small-Conductance Ca²⁺-Activated K⁺ Channel Type 2 (SK2) Modulates Hippocampal Learning, Memory, and Synaptic Plasticity

In the article "Small-Conductance Ca²⁺-Activated K⁺ Channel Type 2 (SK2) Modulates Hippocampal Learning, Memory, and Synaptic Plasticity," by Rebecca S. Hammond, Chris T. Bond, Timothy Strassmaier, Thu Jennifer Ngo-Anh, John P. Adelman, James Maylie, and Robert W. Stackman, which appeared on pages 1844–1853 of the February 8, 2006 issue, the symbols in panels a and b of Figure 6 were reversed. The corrected figure and legend are reprinted here.

View larger version (44K): [in this window] [in a new window]   Figure 6. SK2 overexpression impairs hippocampal-dependent learning and memory in the Morris water maze. a,b, Learning in the hippocampal-independent visible platform water maze task was not different between WT () and SK2+/T () mice as assessed by CDT with swim speed as a covariate (a), ANCOVA (p > 0.05), although SK2+/T mice swam slower than WT mice (b). c,d, Learning in the hippocampal-dependent hidden platform water maze is significantly impaired in SK2+/T mice relative to WT mice (c, p < 0.001), and there were no genotypic differences in swim speed in this version of the task (d, p > 0.05). e, During the final probe test 24 hr after the last hidden platform training trial, SK2+/T mice spent significantly less time in the quadrant of pool relative to the WT mice (p < 0.001). f, Search ratios computed from final probe test data indicate that SK2+/T mice failed to show a spatial bias for the platform location; search ratios were equivalent to chance performance (p > 0.05) and were significantly lower than WT ratios (p < 0.001), indicating that SK2 overexpression severely restricts learning and remembering the location of the hidden platform. Search ratios were defined as the frequency of crossings through a circular zone around the platform location (f, inset) divided by the frequency of crossings into all 4 circular zones. g,h, Representative tracings of swim paths of two WT mice (g) and two SK2+/T mice (h) during the final probe test. Fourteen of the 17 WT mice exhibited platform search patterns similar to that depicted in g, which were characterized as accurate search. In contrast, 8 of the 14 SK2+/T mice exhibited search patterns similar to those depicted in h, which were characterized as random search (left trace) or egocentric search (right trace). All error bars indicate SEM.

 
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