 |
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, May 10, 2006, 26(19):5098-5108; doi:10.1523/JNEUROSCI.5330-05.2006
Previous Article | Next Article
Behavioral/Systems/Cognitive
Sustained Activity in Topographic Areas of Human Posterior Parietal Cortex during Memory-Guided Saccades
Denis Schluppeck, Clayton E. Curtis, Paul W. Glimcher, andDavid J. Heeger Department of Psychology/Center for Neural Science, New York University, New York, New York 10003
Correspondence should be addressed to Denis Schluppeck, Department of Psychology/Center for Neural Science, 4 Washington Place, New York University, New York, NY 10003. Email: ds{at}cns.nyu.edu
In a previous study, we identified three cortical areas in human posterior parietal cortex that exhibited topographic responses during memory-guided saccades [visual area 7 (V7), intraparietal sulcus 1 (IPS1), and IPS2], which are candidate homologs of macaque parietal areas such as the lateral intraparietal area and parietal reach region. Here, we show that these areas exhibit sustained delay-period activity, a critical physiological signature of areas in macaque parietal cortex. By varying delay duration, we disambiguated delay-period activity from sensory and motor responses. Mean time courses in the parietal areas were well fit by a linear model comprising three components representing responses to (1) the visual target, (2) the delay period, and (3) the eye movement interval. We estimated the contributions of each component: the response amplitude during the delay period was substantially smaller (<30%) than that elicited by the transient visual target. All three parietal regions showed comparable delay-period response amplitudes, with a trend toward larger responses from V7 to IPS1 and IPS2. Responses to the cue and during the delay period showed clear lateralization with larger responses to trials in which the target was placed in the contralateral visual field, suggesting that both of these components contributed to the topography we measured.
Key words: parietal cortex; cortical areas; fMRI; saccades; topography; human
Received Dec. 14, 2005; revised March 29, 2006; accepted April 5, 2006.
Correspondence should be addressed to Denis Schluppeck, Department of Psychology/Center for Neural Science, 4 Washington Place, New York University, New York, NY 10003. Email: ds{at}cns.nyu.edu
This article has been cited by other articles:
A. P. Saygin and M. I. Sereno
Retinotopy and Attention in Human Occipital, Temporal, Parietal, and Frontal Cortex
Cereb Cortex, September 1, 2008; 18(9): 2158 - 2168.
[Abstract] [Full Text] [PDF]
C. S. Konen and S. Kastner
Representation of Eye Movements and Stimulus Motion in Topographically Organized Areas of Human Posterior Parietal Cortex
J. Neurosci., August 13, 2008; 28(33): 8361 - 8375.
[Abstract] [Full Text] [PDF]
D. J. Mitchell and R. Cusack
Flexible, Capacity-Limited Activity of Posterior Parietal Cortex in Perceptual as well as Visual Short-Term Memory Tasks
Cereb Cortex, August 1, 2008; 18(8): 1788 - 1798.
[Abstract] [Full Text] [PDF]
K. Morita
Possible Role of Dendritic Compartmentalization in the Spatial Working Memory Circuit
J. Neurosci., July 23, 2008; 28(30): 7699 - 7724.
[Abstract] [Full Text] [PDF]
A. Ikkai and C. E. Curtis
Cortical Activity Time Locked to the Shift and Maintenance of Spatial Attention
Cereb Cortex, June 1, 2008; 18(6): 1384 - 1394.
[Abstract] [Full Text] [PDF]
M. L. LoPresti, K. Schon, M. D. Tricarico, J. D. Swisher, K. A. Celone, and C. E. Stern
Working Memory for Social Cues Recruits Orbitofrontal Cortex and Amygdala: A Functional Magnetic Resonance Imaging Study of Delayed Matching to Sample for Emotional Expressions
J. Neurosci., April 2, 2008; 28(14): 3718 - 3728.
[Abstract] [Full Text] [PDF]
C. C. Ruff, S. Bestmann, F. Blankenburg, O. Bjoertomt, O. Josephs, N. Weiskopf, R. Deichmann, and J. Driver
Distinct Causal Influences of Parietal Versus Frontal Areas on Human Visual Cortex: Evidence from Concurrent TMS-fMRI
Cereb Cortex, April 1, 2008; 18(4): 817 - 827.
[Abstract] [Full Text] [PDF]
A. Bartels, S. Zeki, and N. K. Logothetis
Natural Vision Reveals Regional Specialization to Local Motion and to Contrast-Invariant, Global Flow in the Human Brain
Cereb Cortex, March 1, 2008; 18(3): 705 - 717.
[Abstract] [Full Text] [PDF]
C. E. Curtis and J. D. Connolly
Saccade Preparation Signals in the Human Frontal and Parietal Cortices
J Neurophysiol, January 1, 2008; 99(1): 133 - 145.
[Abstract] [Full Text] [PDF]
T. A. Kelley, J. T. Serences, B. Giesbrecht, and S. Yantis
Cortical Mechanisms for Shifting and Holding Visuospatial Attention
Cereb Cortex, January 1, 2008; 18(1): 114 - 125.
[Abstract] [Full Text] [PDF]
E. Macaluso, C. D. Frith, and J. Driver
Delay Activity and Sensory-Motor Translation During Planned Eye or Hand Movements to Visual or Tactile Targets
J Neurophysiol, November 1, 2007; 98(5): 3081 - 3094.
[Abstract] [Full Text] [PDF]
M. R. G. Brown, T. Vilis, and S. Everling
Frontoparietal Activation With Preparation for Antisaccades
J Neurophysiol, September 1, 2007; 98(3): 1751 - 1762.
[Abstract] [Full Text] [PDF]
I. Indovina and E. Macaluso
Dissociation of Stimulus Relevance and Saliency Factors during Shifts of Visuospatial Attention
Cereb Cortex, July 1, 2007; 17(7): 1701 - 1711.
[Abstract] [Full Text] [PDF]
J. D. Swisher, M. A. Halko, L. B. Merabet, S. A. McMains, and D. C. Somers
Visual Topography of Human Intraparietal Sulcus
J. Neurosci., May 16, 2007; 27(20): 5326 - 5337.
[Abstract] [Full Text] [PDF]
I. Levy, D. Schluppeck, D. J. Heeger, and P. W. Glimcher
Specificity of Human Cortical Areas for Reaches and Saccades
J. Neurosci., April 25, 2007; 27(17): 4687 - 4696.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|