QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, May 10, 2006, 26(19):5190-5197; doi:10.1523/JNEUROSCI.0328-06.2006

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Warland, D. K. Articles by Chalupa, L. M. Search for Related Content PubMed PubMed Citation Articles by Warland, D. K. Articles by Chalupa, L. M.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Dynamics of Spontaneous Activity in the Fetal Macaque Retina during Development of Retinogeniculate Pathways

David K. Warland,¹ Andrew D. Huberman,³ and Leo M. Chalupa^1,2,3

¹Section of Neurobiology, Physiology, and Behavior, College of Biological Sciences, Department of Ophthalmology and Visual Science, ²School of Medicine, and ³Center for Neuroscience, University of California, Davis, Davis, California 95616

Correspondence should be addressed to David K. Warland, Section of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, Davis, CA 95616. Email: dkwarland{at}ucdavis.edu

Correlated spontaneous activity in the form of retinal "waves" has been observed in a wide variety of developing animals, but whether retinal waves occur in the primate has not been determined previously. To address this issue, we recorded from isolated retinas using multielectrode arrays at six fetal ages: embryonic day 51 (E51), E55, E60, E67, E71, and E76. These recordings revealed that the fetal monkey retina is essentially silent at E51 and E55, with only few cells firing on rare occasions and without any obvious spatial or temporal order. Because previous work has shown that the magnocellular and parvocellular subdivisions of the dorsal lateral geniculate are selectively innervated during this early period, our results suggest that this process is unlikely to be regulated by retinal activity. Highly structured retinal waves were first observed at E60, >1 week before the segregation of eye-specific retinal dorsal lateral geniculate nucleus projections commences. The incidence of such waves decreased rapidly and progressively during the developmental period (E67–E76) when segregated eye-specific projections become established. Our findings indicate that retinal waves first occur in the fetal monkey at a remarkably early stage of development, >100 d before birth, and that this activity undergoes rapid changes in salient properties when eye-specific retinogeniculate projections are being formed.

Key words: retina; development; lateral geniculate; lgn; spontaneous activity; primate; retinal waves

---

Received Nov. 2, 2005; revised March 28, 2006; accepted April 1, 2006.

Correspondence should be addressed to David K. Warland, Section of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, Davis, CA 95616. Email: dkwarland{at}ucdavis.edu

This article has been cited by other articles:

				K. D. Murray, C. M. Rubin, E. G. Jones, and L. M. Chalupa Molecular Correlates of Laminar Differences in the Macaque Dorsal Lateral Geniculate Nucleus J. Neurosci., November 12, 2008; 28(46): 12010 - 12022. [Abstract] [Full Text] [PDF]

				J. Cang, L. Wang, M. P. Stryker, and D. A. Feldheim Roles of Ephrin-As and Structured Activity in the Development of Functional Maps in the Superior Colliculus J. Neurosci., October 22, 2008; 28(43): 11015 - 11023. [Abstract] [Full Text] [PDF]

				K. J. Rehm, K. E. Deeg, and E. Marder Developmental Regulation of Neuromodulator Function in the Stomatogastric Ganglion of the Lobster, Homarus americanus J. Neurosci., September 24, 2008; 28(39): 9828 - 9839. [Abstract] [Full Text] [PDF]

				C. Sun, D. K. Warland, J. M. Ballesteros, D. van der List, and L. M. Chalupa Retinal waves in mice lacking the {beta}2 subunit of the nicotinic acetylcholine receptor PNAS, September 9, 2008; 105(36): 13638 - 13643. [Abstract] [Full Text] [PDF]

				K. J. Rehm, A. L. Taylor, S. R. Pulver, and E. Marder Spectral Analyses Reveal the Presence of Adult-Like Activity in the Embryonic Stomatogastric Motor Patterns of the Lobster, Homarus americanus J Neurophysiol, June 1, 2008; 99(6): 3104 - 3122. [Abstract] [Full Text] [PDF]

				C. E. Giacomantonio and G. J. Goodhill The Effect of Angioscotomas on Map Structure in Primary Visual Cortex J. Neurosci., May 2, 2007; 27(18): 4935 - 4946. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help