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The Journal of Neuroscience, May 31, 2006, 26(22):6062-6068; doi:10.1523/JNEUROSCI.5582-05.2006

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Behavioral/Systems/Cognitive
Vibrissa-Signaled Eyeblink Conditioning Induces Somatosensory Cortical Plasticity

Roberto Galvez, Craig Weiss, Aldis P. Weible, and John F. Disterhoft

Department of Physiology and Institute for Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611

Correspondence should be addressed to Roberto Galvez, Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611. Email: r-galvez{at}northwestern.edu

Whisker deflection conditioned stimuli (CS) were demonstrated to activate physiologically and anatomically defined barrels in the contralateral somatosensory cortex and to support trace–eyeblink conditioned responses when paired with corneal airpuff unconditioned stimuli in rabbits. Analysis of cytochrome-oxidase-stained somatosensory whisker-associated cortical barrels revealed a row-specific expansion of the conditioned compared with the nontrained hemisphere. This expansion was not evident in pseudo-conditioned rabbits, suggesting that this expansion of conditioned cortical barrels in response to a hippocampal- and forebrain-dependent learning task (trace conditioning) is associative rather than activity dependent. Using whisker stimulation as a CS in the well studied eyeblink conditioning paradigm will facilitate characterizing sensory cortical involvement in controlling and modulating an associatively learned response at the neural systems and cellular level.

Key words: whisker; barrel; PMBSF; cytochrome oxidase; trace conditioning; hippocampus

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Received Oct. 15, 2005; revised April 27, 2006; accepted April 28, 2006.

Correspondence should be addressed to Roberto Galvez, Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611. Email: r-galvez{at}northwestern.edu

This article has been cited by other articles:

				L. C. Flores and J. F. Disterhoft Caudate Nucleus Is Critically Involved in Trace Eyeblink Conditioning J. Neurosci., November 18, 2009; 29(46): 14511 - 14520. [Abstract] [Full Text] [PDF]

				M. J. Miller, C. Weiss, X. Song, G. Iordanescu, J. F. Disterhoft, and A. M. Wyrwicz Functional Magnetic Resonance Imaging of Delay and Trace Eyeblink Conditioning in the Primary Visual Cortex of the Rabbit J. Neurosci., May 7, 2008; 28(19): 4974 - 4981. [Abstract] [Full Text] [PDF]

				J. Troncoso, A. Munera, and J. M. Delgado-Garcia Learning-dependent potentiation in the vibrissal motor cortex is closely related to the acquisition of conditioned whisker responses in behaving mice Learn. Mem., January 1, 2007; 14(1-2): 84 - 93. [Abstract] [Full Text] [PDF]

				R. Galvez, A. P. Weible, and J. F. Disterhoft Cortical barrel lesions impair whisker-CS trace eyeblink conditioning Learn. Mem., January 1, 2007; 14(1-2): 94 - 100. [Abstract] [Full Text] [PDF]

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