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The Journal of Neuroscience, June 14, 2006, 26(24):6485-6495; doi:10.1523/JNEUROSCI.5061-05.2006

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Behavioral/Systems/Cognitive
Receptive Field (RF) Properties of the Macaque Second Somatosensory Cortex: RF Size, Shape, and Somatotopic Organization

Paul J. Fitzgerald, John W. Lane, Pramodsingh H. Thakur, and Steven S. Hsiao

Zanvyl Krieger Mind/Brain Institute, Departments of Neuroscience and Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218

Correspondence should be addressed to Dr. Steven Hsiao, Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, 338 Krieger Hall, 3400 North Charles Street, Baltimore, MD 21218. Email: steven.hsiao{at}jhu.edu

The detailed structure of multidigit receptive fields (RFs) in somatosensory cortical areas such as the SII region has not been investigated previously using systematically controlled stimuli. Recently (Fitzgerald et al., 2004), we showed that the SII region comprises three adjoining fields: posterior, central, and anterior. Here we characterize the RF structures of the 928 neurons that were reported in that study using a motorized oriented bar that was indented into the 12 finger pads of digits 2–5. Most (81%) of the neurons were responsive to the oriented bar stimuli, and 81% of those neurons had RFs that spanned multiple digits. Furthermore, the RFs varied greatly in size, shape, and complexity. Some RFs contained only excitatory finger pads, some contained only inhibitory pads, and some contained both types of pads. A subset of the neurons (23%) showed orientation tuning within one or more pads. The RFs spread across different digits more than within individual digits, and the responsive finger pads for a given neuron tended to cluster together within the hand. Distal and lateral finger pads were better represented than proximal and medial finger pads. Furthermore, neurons in the posterior, central, and anterior SII region fields contained different proportions of RF types. These results collectively indicate that most SII region neurons are selective for different stimulus forms either within single finger pads or across multiple pads. We hypothesize that these RFs represent the kernels underlying the representation of tactile shape.

Key words: somatosensory cortex; tactile; SII; orientation; receptive field; somatotopy

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Received June 8, 2005; revised May 11, 2006; accepted May 12, 2006.

Correspondence should be addressed to Dr. Steven Hsiao, Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, 338 Krieger Hall, 3400 North Charles Street, Baltimore, MD 21218. Email: steven.hsiao{at}jhu.edu

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