QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, July 5, 2006, 26(27):7156-7162; doi:10.1523/JNEUROSCI.0906-06.2006

This Article Full Text Full Text (PDF) Supplemental data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (17) Citing Articles via Google Scholar Google Scholar Articles by Chuah, Y. M. L. Articles by Chee, M. W. L. Search for Related Content PubMed PubMed Citation Articles by Chuah, Y. M. L. Articles by Chee, M. W. L.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation

Y. M. Lisa Chuah,¹ Vinod Venkatraman,¹ David F. Dinges,² and Michael W. L. Chee¹

¹Cognitive Neuroscience Laboratory, Singapore Health Services, Singapore, 169611, and ²Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6021

Correspondence should be addressed to Dr. Michael W. L. Chee, Cognitive Neuroscience Laboratory, Singapore Health Services, 7 Hospital Drive, #01-11, Block B, SingHealth Research Facilities, Singapore, 169611. Email: mchee{at}pacific.net.sg

Sleep deprivation results in the loss of our ability to suppress a prepotent response. The extent of decline in this executive function varies across individuals. Here, we used functional magnetic resonance imaging to study the neural correlates of sleep deprivation-induced differences in inhibitory efficiency. Participants performed a go/no-go task after normal sleep and after 24 h of total sleep deprivation. Regardless of the extent of change in inhibitory efficiency, sleep deprivation lowered go/no-go sustained, task-related activation of the ventral and anterior prefrontal (PFC) regions bilaterally. However, individuals better able to maintain inhibitory efficiency after sleep deprivation could be distinguished by lower stop-related, phasic activation of the right ventral PFC during rested wakefulness. These persons also showed a larger rise in such activation both here and in the right insula after sleep deprivation relative to those whose inhibitory efficiency declined.

Key words: go/no-go; inhibition; error monitoring; compensation; functional neuroimaging; prefrontal cortex

---

Received March 1, 2006; revised May 26, 2006; accepted May 26, 2006.

Correspondence should be addressed to Dr. Michael W. L. Chee, Cognitive Neuroscience Laboratory, Singapore Health Services, 7 Hospital Drive, #01-11, Block B, SingHealth Research Facilities, Singapore, 169611. Email: mchee{at}pacific.net.sg

This article has been cited by other articles:

				G. Vandewalle, S. N. Archer, C. Wuillaume, E. Balteau, C. Degueldre, A. Luxen, P. Maquet, and D.-J. Dijk Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype J. Neurosci., June 24, 2009; 29(25): 7948 - 7956. [Abstract] [Full Text] [PDF]

				D. Tomasi, R.L. Wang, F. Telang, V. Boronikolas, M.C. Jayne, G.-J. Wang, J.S. Fowler, and N.D. Volkow Impairment of Attentional Networks after 1 Night of Sleep Deprivation Cereb Cortex, January 1, 2009; 19(1): 233 - 240. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help