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The Journal of Neuroscience, July 19, 2006, 26(29):7575-7580; doi:10.1523/JNEUROSCI.5083-05.2006

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Cellular/Molecular
Visual Experience Regulates Metabotropic Glutamate Receptor-Mediated Plasticity of AMPA Receptor Synaptic Transmission by Homer1a Induction

Kendall Van Keuren-Jensen¹ and Hollis T. Cline²

¹Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, New York 11794-5230, and ²Department of Neuroscience, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724

Correspondence should be addressed to Hollis T. Cline, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724. Email: cline{at}cshl.org

Brief metabotropic glutamate receptor (mGluR) activation leads to plasticity of AMPA receptor (AMPAR) synaptic transmission. To test whether mGluR-mediated plasticity of AMPAR transmission is influenced by recent neuronal activity, we manipulated visual activity in Xenopus laevis tadpoles in vivo. We compared mGluR-mediated plasticity of AMPAR transmission in optic tectal cells of tadpoles with low levels of previous synaptic activity (overnight in the dark) to transmission in neurons from animals after 4 h of constant visual stimulation. mGluR-mediated plasticity of AMPA transmission was significantly decreased in neurons with recent activity. We tested the role of the activity-regulated mGluR scaffolding protein Homer1a in modulating mGluR-mediated changes in AMPAR transmission. We found that, by changing the ratios of Homer 1a to Homer 1b in vivo, by either induction of endogenous Homer1a by visual activity or ectopic expression of Homer1a or Homer1b, we could change the direction of mGluR-mediated plasticity. This is the first evidence that mGluR-mediated changes in AMPA transmission can be regulated by Homer proteins in response to physiologically relevant stimuli.

Key words: synaptic plasticity; Xenopus; metaplasticity; Homer; mGluR; experience-dependent; homeostasis; retinotectal

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Received Nov. 29, 2005; revised June 1, 2006; accepted June 2, 2006.

Correspondence should be addressed to Hollis T. Cline, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724. Email: cline{at}cshl.org

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