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The Journal of Neuroscience, August 2, 2006, 26(31):8176-8182; doi:10.1523/JNEUROSCI.1641-06.2006

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Behavioral/Systems/Cognitive
The Anterior Intraparietal Sulcus Mediates Grasp Execution, Independent of Requirement to Update: New Insights from Transcranial Magnetic Stimulation

Nichola J. Rice, Eugene Tunik, and Scott T. Grafton

Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755

Correspondence should be addressed to Scott T. Grafton, Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, HB 6162 Moore Hall, Dartmouth College, Hanover, NH 03755. Email: scott.t.grafton{at}dartmouth.edu

Although a role of the intraparietal sulcus (IPS) in grasping is becoming evident, the specific contribution of regions within the IPS remains undefined. In this vein, transcranial magnetic stimulation (TMS) was delivered to the anterior (aIPS), middle (mIPS), and caudal (cIPS) IPS in two tasks designed to dissociate the potential roles of the IPS in either grasp planning or execution (task 1) and its involvement in error detection or error correction (task 2). Determining the involvement of specific regions of the IPS in perceptual (planning and error detection) versus motor (execution and correction) components of grasping allowed us to assess the ecological validity of competing computational models attempting to simulate reach-to-grasp movements. In task 1, we demonstrate that, when no on-line adjustment is necessary, TMS to aIPS (but not mIPS or cIPS) disrupts grasping; this disruption is only elicited when TMS is applied during the execution (but not the planning) phase of the movement. Task 2 reveals that TMS to aIPS (but not mIPS or cIPS) disrupts grasping in the presence of a perturbation; this disruption is only elicited when TMS is applied during the error correction (but not error detection) phase of the movement. We propose that the specific contribution of the aIPS in grasping is in the on-line computation of a difference vector based on motor goal, efference copy, and sensory inputs. This computation is performed for both stable and perturbed motor goals.

Key words: motor control; grasping; intraparietal sulcus; dorsal stream; computational models; perception and action

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Received April 17, 2006; revised July 3, 2006; accepted July 5, 2006.

Correspondence should be addressed to Scott T. Grafton, Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, HB 6162 Moore Hall, Dartmouth College, Hanover, NH 03755. Email: scott.t.grafton{at}dartmouth.edu

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