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The Journal of Neuroscience, August 9, 2006, 26(32):8278-8288; doi:10.1523/JNEUROSCI.1231-06.2006

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Cellular/Molecular
Compensation of Inositol 1,4,5-Trisphosphate Receptor Function by Altering Sarco-Endoplasmic Reticulum Calcium ATPase Activity in the Drosophila Flight Circuit

Santanu Banerjee, Rohit Joshi, Gayatri Venkiteswaran, Neha Agrawal, Sonal Srikanth, Farhan Alam, and Gaiti Hasan

National Center for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560 065, India

Correspondence should be addressed to Gaiti Hasan, National Center for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560 065, India. Email: gaiti{at}ncbs.res.in

Ionic Ca²⁺ functions as a second messenger to control several intracellular processes. It also influences intercellular communication. The release of Ca²⁺ from intracellular stores through the inositol 1,4,5-trisphosphate receptor (InsP₃R) occurs in both excitable and nonexcitable cells. In Drosophila, InsP₃R activity is required in aminergic interneurons during pupal development for normal flight behavior. By altering intracellular Ca²⁺ and InsP₃ levels through genetic means, we now show that signaling through the InsP₃R is required at multiple steps for generating the neural circuit required in air puff-stimulated Drosophila flight. Decreased Ca²⁺ release in aminergic neurons during development of the flight circuit can be compensated by reducing Ca²⁺ uptake from the cytosol to intracellular stores. However, this mode of increasing intracellular Ca²⁺ is insufficient for maintenance of flight patterns over time periods necessary for normal flight. Our study suggests that processes such as maintenance of wing posture and formation of the flight circuit require InsP₃ receptor function at a slow timescale and can thus be modulated by altering levels of cytosolic Ca²⁺ and InsP_3. In contrast, maintenance of flight patterns probably requires fast modulation of Ca²⁺ levels, in which the intrinsic properties of the InsP₃R play a pivotal role.

Key words: InsP₃ receptor; SERCA; aminergic interneurons; Gq; phospholipase C; flight patterns

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Received March 22, 2006; revised July 6, 2006; accepted July 6, 2006.

Correspondence should be addressed to Gaiti Hasan, National Center for Biological Sciences, Tata Institute of Fundamental Research, Bellary Road, Bangalore 560 065, India. Email: gaiti{at}ncbs.res.in

This article has been cited by other articles:

				P. Kain, T. S. Chakraborty, S. Sundaram, O. Siddiqi, V. Rodrigues, and G. Hasan Reduced Odor Responses from Antennal Neurons of Gq{alpha}, Phospholipase C{beta}, and rdgA Mutants in Drosophila Support a Role for a Phospholipid Intermediate in Insect Olfactory Transduction J. Neurosci., April 30, 2008; 28(18): 4745 - 4755. [Abstract] [Full Text] [PDF]

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