WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, September 6, 2006, 26(36):9135-9141; doi:10.1523/JNEUROSCI.4869-05.2006

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental data
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilbrecht, L.
Right arrow Articles by Nottebohm, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilbrecht, L.
Right arrow Articles by Nottebohm, F.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
High Levels of New Neuron Addition Persist When the Sensitive Period for Song Learning Is Experimentally Prolonged

Linda Wilbrecht,1,4 Heather Williams,2 Nidhi Gangadhar,1,3 and Fernando Nottebohm1

1Laboratory of Animal Behavior, Rockefeller University, New York, New York 10021, 2Biology Department, Williams College, Williamstown, Massachusetts 01267, 3Department of Biological Sciences, Columbia University, New York, New York 10027, and 4Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724

Correspondence should be addressed to Dr. Linda Wilbrecht, 1 Bungtown Road, Svoboda Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724. Email: wilbrech{at}cshl.org

Socially reared zebra finch males imitate a song they hear during posthatching days 30–65; during this time, many new neurons are added to the high vocal center (HVC), a forebrain nucleus necessary for the production of learned song. New neuron addition drops sharply after day 65, and no new songs are imitated. In contrast, male zebra finches reared in isolation from other males have more variable songs at day 65 and thereafter can still imitate new sounds (Eales, 1985). We show that, in isolate birds, a greater number of new neurons continues to be added to HVC during the next 85 d, and this number correlates with syllable variability. We suggest that new neuron addition and turnover facilitate song change and that this effect lingers when an expected learning event is delayed.

Key words: neurogenesis; learning and memory; BrdU; birdsong; neuroethology; deprivation

Received Nov. 11, 2005; revised June 29, 2006; accepted July 25, 2006.

Correspondence should be addressed to Dr. Linda Wilbrecht, 1 Bungtown Road, Svoboda Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724. Email: wilbrech{at}cshl.org




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Li, X.-J. Wang, J. Tannenhauser, S. Podell, P. Mukherjee, M. Hertel, J. Biane, S. Masuda, F. Nottebohm, and T. Gaasterland
Genomic resources for songbird research and their use in characterizing gene expression during brain development
PNAS, April 17, 2007; 104(16): 6834 - 6839.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-