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The Journal of Neuroscience, September 20, 2006, 26(38):9683-9694; doi:10.1523/JNEUROSCI.5495-05.2006

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Behavioral/Systems/Cognitive
Modulation of Transient and Sustained Response Components of V4 Neurons by Temporal Crowding in Flashed Stimulus Sequences

Brad C. Motter

Veterans Affairs Medical Center, Syracuse, New York 13210, and Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York 13210

Correspondence should be addressed to Brad C. Motter, Research Service 151, Veterans Affairs Medical Center, 800 Irving Avenue, Syracuse, NY 13210. Email: motterb{at}cnyrc.org

The responses of extrastriate area V4 neurons to flashed visual stimuli were examined to determine whether the responses to stimulus sequences occurring at normal saccade and fixation timing intervals were degraded relative to longer timing intervals. Stimuli were flashed in receptive fields in the near periphery while monkeys maintained steady fixation. Short interstimulus intervals (ISIs) resulted in an overall habituation style response reduction. The transient component of responses to preferred stimuli was suppressed, often completely, when the ISI was reduced below 100 ms into the range of saccadic durations. The sustained response component weakened but remained intact. At short ISIs the trailing activity from the preceding stimulus blended with onset activity from the next stimulus, making it difficult to detect individual stimulus onset events within the spike train. Habituation or conditioning effects were correlated with the stimulus tuning sensitivity of the neuron but only loosely associated with the actual level of V4 activation elicited by preceding stimuli. The results suggest that sharply tuned neurons, because of their probabilistic inactivity, are particularly sensitive to temporal change, whereas the sustained components of broadly tuned neurons could provide a continuity of information flow across visual transients, such as saccades, that do not alter significantly the view by the neuron of the scene.

Key words: macaque; extrastriate; receptive field; temporal coding; crowding; RSVP

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Received Dec. 22, 2005; revised July 20, 2006; accepted Aug. 8, 2006.

Correspondence should be addressed to Brad C. Motter, Research Service 151, Veterans Affairs Medical Center, 800 Irving Avenue, Syracuse, NY 13210. Email: motterb{at}cnyrc.org

Related articles in J. Neurosci.:

Two's a Crowd: Suppressed V4 Visual Responses to Sequential Stimuli

J. Patrick Mayo
J. Neurosci. 2007 27: 723-724. [Full Text]  

This article has been cited by other articles:

				B. C. Motter Central V4 Receptive Fields Are Scaled by the V1 Cortical Magnification and Correspond to a Constant-Sized Sampling of the V1 Surface J. Neurosci., May 6, 2009; 29(18): 5749 - 5757. [Abstract] [Full Text] [PDF]

				J. P. Mayo and M. A. Sommer Neuronal Adaptation Caused by Sequential Visual Stimulation in the Frontal Eye Field J Neurophysiol, October 1, 2008; 100(4): 1923 - 1935. [Abstract] [Full Text] [PDF]

				J. P. Mayo Two's a Crowd: Suppressed V4 Visual Responses to Sequential Stimuli J. Neurosci., January 24, 2007; 27(4): 723 - 724. [Full Text] [PDF]

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