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The Journal of Neuroscience, September 20, 2006, 26(38):9695-9702; doi:10.1523/JNEUROSCI.2014-06.2006

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Behavioral/Systems/Cognitive
Area Postrema Neurons Are Modulated by the Adipocyte Hormone Adiponectin

Mark Fry,¹ Pauline M. Smith,¹ Ted D. Hoyda,¹ Marnie Duncan,² Rexford S. Ahima,³ Keith A. Sharkey,² and Alastair V. Ferguson¹

¹Department of Physiology, Queen's University, Kingston, Ontario, Canada, K7L 3N6, ²Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada, T2N 4N1, and ³Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104

Correspondence should be addressed to Alastair Ferguson, Department of Physiology, Faculty of Life Sciences, Queen's University, Kingston, Ontario, Canada, K7L 3N6. Email: avf{at}post.queensu.ca

Adiponectin is an adipocyte-derived peptide hormone involved in energy homeostasis and the pathogenesis of obesity, including hypertension. Area postrema (AP) lacks a blood–brain barrier and is a critical homeostatic integration center for humoral and neural signals. Here we investigate the role of AP in adiponectin signaling. We show that rat AP expresses AdipoR1 and AdipoR2 adiponectin receptor mRNA. We used current-clamp electrophysiology to investigate whether adiponectin influenced membrane properties of AP neurons and found that 60% of rat AP neurons tested were sensitive to adiponectin. Additional electrophysiology experiments coupled with single-cell reverse transcription-PCR indicated that all neurons that expressed both subtypes of receptor were sensitive to adiponectin, whereas neurons expressing only one subtype were predominantly insensitive. Last, microinjection of adiponectin into AP caused significant increases in arterial blood pressure, with no change in heart rate, suggesting that adiponectin acts at AP to provide a possible link between control of energy homeostasis and cardiovascular function.

Key words: adiponectin; area postrema; circumventricular organ; patch clamp; microinjection; homeostasis

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Received May 10, 2006; revised Aug. 9, 2006; accepted Aug. 9, 2006.

Correspondence should be addressed to Alastair Ferguson, Department of Physiology, Faculty of Life Sciences, Queen's University, Kingston, Ontario, Canada, K7L 3N6. Email: avf{at}post.queensu.ca

This article has been cited by other articles:

				R. S. Ahima and M. A. Lazar Adipokines and the Peripheral and Neural Control of Energy Balance Mol. Endocrinol., May 1, 2008; 22(5): 1023 - 1031. [Abstract] [Full Text] [PDF]

				E. D. Abel, S. E. Litwin, and G. Sweeney Cardiac Remodeling in Obesity Physiol Rev, April 1, 2008; 88(2): 389 - 419. [Abstract] [Full Text] [PDF]

				C. J. Price, T. D. Hoyda, and A. V. Ferguson The Area Postrema: A Brain Monitor and Integrator of Systemic Autonomic State Neuroscientist, April 1, 2008; 14(2): 182 - 194. [Abstract] [PDF]

				T. D. Hoyda, M. Fry, R. S. Ahima, and A. V. Ferguson Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamus J. Physiol., December 15, 2007; 585(3): 805 - 816. [Abstract] [Full Text] [PDF]

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