WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, January 25, 2006, 26(4):1154-1163; doi:10.1523/JNEUROSCI.4424-05.2006

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental data
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (5)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, A. B.
Right arrow Articles by Fallon, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, A. B.
Right arrow Articles by Fallon, J. R.

 Previous Article  |  Next Article 

Cellular/Molecular
Dendrites Contain a Spacing Pattern

Aaron B. Taylor and Justin R. Fallon

Department of Neuroscience, Brown University, Providence, Rhode Island 02912

Correspondence should be addressed to Aaron Taylor, Department of Neuroscience, Brown University, Box 1953, 190 Thayer Street, Providence, RI 02912. Email: aaron_taylor{at}brown.edu

The distinctive branching patterns of dendritic arbors are essential for neuronal information processing. The final shape of an arbor is the result of intrinsic and extrinsic factors. However, the cellular mechanisms that underlie branch patterning are unknown. In many biological systems, locally acting factors are intrinsically organized into spacing patterns that guide patterned morphogenesis. Here, we show that neurons contain two types of periodic and regular elements (PADREN1s and PADREN2s) that are arranged into a spacing pattern. The wavelength of the pattern is ~20 µm. Dendritic branches occur preferentially within PADREN1s, and specific PADREN lengths correspond to specific arbor types. The lengths of the PADRENs also change over time and can be modified by activity. However, PADRENs are intrinsically organized, possibly by a reaction-diffusion process. PADRENs reveal a previously unrecognized level of neuronal organization that may provide insight into how the distinct branching patterns of the dendrites are intrinsically organized.

Key words: dendrite; arbor; branching; morphology; pattern; branch spacing

Received Jun. 23, 2005; revised Dec. 7, 2005; accepted Dec. 12, 2005.

Correspondence should be addressed to Aaron Taylor, Department of Neuroscience, Brown University, Box 1953, 190 Thayer Street, Providence, RI 02912. Email: aaron_taylor{at}brown.edu




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
G. Frugier, F. Coussen, M.-F. Giraud, M.-F. Odessa, M. B. Emerit, E. Boue-Grabot, and M. Garret
A {gamma}2(R43Q) Mutation, Linked to Epilepsy in Humans, Alters GABAA Receptor Assembly and Modifies Subunit Composition on the Cell Surface
J. Biol. Chem., February 9, 2007; 282(6): 3819 - 3828.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-