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The Journal of Neuroscience, October 4, 2006, 26(40):10232-10234; doi:10.1523/JNEUROSCI.2101-06.2006

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Brief Communications
Sparse Representation in the Human Medial Temporal Lobe

Stephen Waydo,¹ Alexander Kraskov,² Rodrigo Quian Quiroga,³ Itzhak Fried,^4,5 and Christof Koch²

¹Control and Dynamical Systems and ²Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, ³Department of Engineering, University of Leicester, Leicester LE1 7RH, United Kingdom, ⁴Division of Neurosurgery and Neuropsychiatric Institute, University of California, Los Angeles, Los Angeles, California 90095, and ⁵Functional Neurosurgery Unit, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel

Correspondence should be addressed to Stephen Waydo, Control and Dynamical Systems, California Institute of Technology, 1200 East California Boulevard, M/C 107-81, Pasadena, CA 91125. Email: waydo{at}cds.caltech.edu

Recent experiments characterized individual neurons in the human medial temporal lobe with remarkably selective, invariant, and explicit responses to images of famous individuals or landmark buildings. Here, we used a probabilistic analysis to show that these data are consistent with a sparse code in which neurons respond in a selective manner to a small fraction of stimuli.

Key words: representation; sparseness; MTL; hippocampus; memory; neural coding

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Received May 17, 2006; revised Aug. 2, 2006; accepted Aug. 29, 2006.

Correspondence should be addressed to Stephen Waydo, Control and Dynamical Systems, California Institute of Technology, 1200 East California Boulevard, M/C 107-81, Pasadena, CA 91125. Email: waydo{at}cds.caltech.edu

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