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The Journal of Neuroscience, October 11, 2006, 26(41):10380-10386; doi:10.1523/JNEUROSCI.3863-06.2006

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Symposia and Mini-Symposia
Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits

Karl Deisseroth,^1,2 Guoping Feng,⁵ Ania K. Majewska,⁶ Gero Miesenböck,⁷ Alice Ting,⁸ and Mark J. Schnitzer^3,4

Departments of ¹Bioengineering, ²Psychiatry and Behavioral Sciences, ³Biological Sciences, and ⁴Applied Physics, Stanford University, Stanford, California 94305, ⁵Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27708, ⁶Department of Neurobiology and Anatomy, University of Rochester, Rochester, New York 14627, ⁷Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06536, and ⁸Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Correspondence should be addressed to either Karl Deisseroth or Mark J. Schnitzer. Email: deissero{at}stanford.edu or Email: mschnitz{at}stanford.edu

Emerging technologies from optics, genetics, and bioengineering are being combined for studies of intact neural circuits. The rapid progression of such interdisciplinary "optogenetic" approaches has expanded capabilities for optical imaging and genetic targeting of specific cell types. Here we explore key recent advances that unite optical and genetic approaches, focusing on promising techniques that either allow novel studies of neural dynamics and behavior or provide fresh perspectives on classic model systems.

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Received Sept. 5, 2006; revised Sept. 24, 2006; accepted Sept. 25, 2006.

Correspondence should be addressed to either Karl Deisseroth or Mark J. Schnitzer. Email: deissero{at}stanford.edu or Email: mschnitz{at}stanford.edu

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