QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, October 25, 2006, 26(43):11131-11137; doi:10.1523/JNEUROSCI.2744-06.2006

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (19) Citing Articles via Google Scholar Google Scholar Articles by Abrams, D. A. Articles by Kraus, N. Search for Related Content PubMed PubMed Citation Articles by Abrams, D. A. Articles by Kraus, N.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Auditory Brainstem Timing Predicts Cerebral Asymmetry for Speech

Daniel A. Abrams,¹ Trent Nicol,¹ Steven G. Zecker,¹ and Nina Kraus^1,2

¹Auditory Neuroscience Laboratory, Department of Communication Sciences, and ²Departments of Neurobiology and Physiology and Otolaryngology, Northwestern University, Evanston, Illinois 60208

Correspondence should be addressed to Daniel A. Abrams, 2240 Campus Drive, Evanston, IL 60208. Email: daabrams{at}northwestern.edu

The left hemisphere of the human cerebral cortex is dominant for processing rapid acoustic stimuli, including speech, and this specialized activity is preceded by processing in the auditory brainstem. It is not known to what extent the integrity of brainstem encoding of speech impacts patterns of asymmetry at cortex. Here, we demonstrate that the precision of temporal encoding of speech in auditory brainstem predicts cerebral asymmetry for speech sounds measured in a group of children spanning a range of language skills. Results provide strong evidence that timing deficits measured at the auditory brainstem negatively impact rapid acoustic processing by specialized structures of cortex, and demonstrate a delicate relationship between cortical activation patterns and the temporal integrity of cortical input.

Key words: auditory brainstem; auditory cortex; reading; dyslexia; cerebral asymmetry; speech

---

Received June 27, 2006; revised Sept. 12, 2006; accepted Sept. 17, 2006.

Correspondence should be addressed to Daniel A. Abrams, 2240 Campus Drive, Evanston, IL 60208. Email: daabrams{at}northwestern.edu

This article has been cited by other articles:

				K. Banai, J. Hornickel, E. Skoe, T. Nicol, S. Zecker, and N. Kraus Reading and Subcortical Auditory Function Cereb Cortex, November 1, 2009; 19(11): 2699 - 2707. [Abstract] [Full Text] [PDF]

				J. Hornickel, E. Skoe, T. Nicol, S. Zecker, and N. Kraus Subcortical differentiation of stop consonants relates to reading and speech-in-noise perception PNAS, August 4, 2009; 106(31): 13022 - 13027. [Abstract] [Full Text] [PDF]

				D. A. Abrams, T. Nicol, S. Zecker, and N. Kraus Abnormal Cortical Processing of the Syllable Rate of Speech in Poor Readers J. Neurosci., June 17, 2009; 29(24): 7686 - 7693. [Abstract] [Full Text] [PDF]

				S. B. Amin, D. Prinzing, and G. Myers Hyperbilirubinemia and Language Delay in Premature Infants Pediatrics, January 1, 2009; 123(1): 327 - 331. [Abstract] [Full Text] [PDF]

				D. A. Abrams, T. Nicol, S. Zecker, and N. Kraus Right-Hemisphere Auditory Cortex Is Dominant for Coding Syllable Patterns in Speech J. Neurosci., April 9, 2008; 28(15): 3958 - 3965. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help