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The Journal of Neuroscience, December 6, 2006, 26(49):12642-12646; doi:10.1523/JNEUROSCI.3530-06.2006

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Brief Communications
Tumor Necrosis Factor Potentiates Central Vagal Afferent Signaling by Modulating Ryanodine Channels

Richard C. Rogers, Montina J. Van Meter, and Gerlinda E. Hermann

Laboratory of Autonomic Neuroscience, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808

Correspondence should be addressed to Richard C. Rogers, Laboratory of Autonomic Neuroscience, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808. Email: rogersrc{at}pbrc.edu

Disease processes such as infection, leukemia, and autoimmune disorders are often associated with nausea, emesis, and anorexia. A common denominator of these rather disparate states is the production of the early, proinflammatory cytokine tumor necrosis factor- (TNF) in significant quantities. Recent studies have shown that TNF may act as a neuromodulator in the hindbrain to produce malaise by potentiating visceral afferent signaling at the central processes of the vagus nerve. However, the mechanism by which TNF produces this signal amplification is not known. Our time-lapse calcium imaging studies of individual central vagal afferent varicosities in the caudal brainstem slice preparation show that, although TNF has minimal direct effects to elevate terminal intracellular calcium levels, TNF does potentiate the terminal afferent responses to other stimuli through a ryanodine-based, calcium-induced calcium release mechanism. Such a scheme may explain how TNF sensitizes visceral as well as somatosensory primary afferents.

Key words: calcium imaging; cytokine; CD38; c-ADPR; brainstem; visceral afferents

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Received Aug. 15, 2006; revised Sept. 28, 2006; accepted Oct. 26, 2006.

Correspondence should be addressed to Richard C. Rogers, Laboratory of Autonomic Neuroscience, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808. Email: rogersrc{at}pbrc.edu

This article has been cited by other articles:

				G. E. Hermann, M. J. Van Meter, J. C. Rood, and R. C. Rogers Proteinase-Activated Receptors in the Nucleus of the Solitary Tract: Evidence for Glial-Neural Interactions in Autonomic Control of the Stomach J. Neurosci., July 22, 2009; 29(29): 9292 - 9300. [Abstract] [Full Text] [PDF]

				M. A. Motagally, M. K. Lukewich, S. P. Chisholm, S. Neshat, and A. E. Lomax Tumour necrosis factor \#945; activates nuclear factor \#954;B signalling to reduce N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons J. Physiol., June 1, 2009; 587(11): 2623 - 2634. [Abstract] [Full Text] [PDF]

				G. E. Hermann and R. C. Rogers TNF {alpha}: A Trigger of Autonomic Dysfunction Neuroscientist, February 1, 2008; 14(1): 53 - 67. [Abstract] [PDF]

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