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The Journal of Neuroscience, February 1, 2006, 26(5):1531-1538; doi:10.1523/JNEUROSCI.4636-05.2006

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Development/Plasticity/Repair
Retinoid-Related Orphan Receptor Controls the Early Steps of Purkinje Cell Dendritic Differentiation

Fatiha Boukhtouche,¹ Sonja Janmaat,¹ Guilan Vodjdani,² Vanessa Gautheron,¹ Jacques Mallet,² Isabelle Dusart,¹ and Jean Mariani¹

¹Université Pierre et Marie Curie–Paris6, Unité Mixte de Recherche (UMR) 7102–Neurobiologie des Processus Adaptatifs (NPA); Centre National de la Recherche Scientifique (CNRS), UMR 7102–NPA, Paris, F-75005 France, and ²Université Pierre et Marie Curie–Paris6, UMR 7091–Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs (LGN); CNRS, UMR 7091–LGN, Paris, F-75013 France

Correspondence should be addressed to Fatiha Boukhtouche, Neurobiologie des Processus Adaptatifs, Unité Mixte de Recherche 7102, Université Pierre et Marie Curie Case 14, 9 quai St-Bernard, 75005 Paris, France. Email: fatiha.boukhtouche{at}snv.jussieu.fr

Dendritic differentiation involves both regressive and growth events. The mechanisms controlling the regressive events are poorly understood. This study is aimed at determining the role of the nuclear receptor retinoid-related orphan receptor (ROR) in Purkinje cell (PC) dendritic differentiation in organotypic cultures. As observed in vivo, in these cultures, fusiform PCs with embryonic bipolar shape undergo regression before the outgrowth of the ultimate dendritic tree. We show that lentiviral-mediated hROR1 overexpression in fusiform PCs leads to a cell-autonomous accelerated progression of dendritic differentiation. In addition, ROR is necessary for the PC regressive events: whereas staggerer ROR-deficient PCs remain in the embryonic fusiform stage, replacement of hROR1 restores normal dendritogenesis. These results demonstrate that ROR expression in fusiform PCs is crucial for the dendritic regression and progression of the following step of extension of dendritic processes. However, it does not seem to participate to the last stage of dendritic growth. This study identifies ROR as a nuclear receptor crucial for the control of dendritic remodeling during development.

Key words: ROR; Purkinje cells; dendritic regression; differentiation; lentiviral vector; organotypic culture

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Received Oct. 28, 2005; revised Dec. 15, 2005; accepted Dec. 18, 2005.

Correspondence should be addressed to Fatiha Boukhtouche, Neurobiologie des Processus Adaptatifs, Unité Mixte de Recherche 7102, Université Pierre et Marie Curie Case 14, 9 quai St-Bernard, 75005 Paris, France. Email: fatiha.boukhtouche{at}snv.jussieu.fr

This article has been cited by other articles:

				F. E. Poulain, S. Chauvin, R. Wehrle, M. Desclaux, J. Mallet, G. Vodjdani, I. Dusart, and A. Sobel SCLIP Is Crucial for the Formation and Development of the Purkinje Cell Dendritic Arbor J. Neurosci., July 16, 2008; 28(29): 7387 - 7398. [Abstract] [Full Text] [PDF]

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