QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, December 13, 2006, 26(50):12873-12884; doi:10.1523/JNEUROSCI.3595-06.2006

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Pfeiffenberger, C. Articles by Feldheim, D. A. Search for Related Content PubMed PubMed Citation Articles by Pfeiffenberger, C. Articles by Feldheim, D. A.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Ephrin-As and Patterned Retinal Activity Act Together in the Development of Topographic Maps in the Primary Visual System

Cory Pfeiffenberger, Jena Yamada, and David A. Feldheim

Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064

Correspondence should be addressed to David A. Feldheim, University of California Santa Cruz, 428 Sinsheimer Laboratories, Santa Cruz, CA 95064. Email: Feldheim{at}biology.ucsc.edu

The development of topographic maps in the primary visual system is thought to rely on a combination of EphA/ephrin-A interactions and patterned neural activity. Here, we characterize the retinogeniculate and retinocollicular maps of mice mutant for ephrins-A2, -A3, and -A5 (the three ephrin-As expressed in the mouse visual system), mice mutant for the ß2 subunit of the nicotinic acetylcholine receptor (that lack early patterned retinal activity), and mice mutant for both ephrin-As and ß2. We also provide the first comprehensive anatomical description of the topographic connections between the retina and the dorsal lateral geniculate nucleus. We find that, although ephrin-A2/A3/A5 triple knock-out mice have severe mapping defects in both projections, they do not completely lack topography. Mice lacking ß2-dependent retinal activity have nearly normal topography but fail to refine axonal arbors. Mice mutant for both ephrin-As and ß2 have synergistic mapping defects that result in a near absence of map in the retinocollicular projection; however, the retinogeniculate projection is not as severely disrupted as the retinocollicular projection is in these mutants. These results show that ephrin-As and patterned retinal activity act together to establish topographic maps, and demonstrate that midbrain and forebrain connections have a differential requirement for ephrin-As and patterned retinal activity in topographic map development.

Key words: ephrin; dorsal lateral geniculate nucleus; superior colliculus; anterograde labeling; axon guidance; development; retina; retinogeniculate; retinotectal

---

Received Aug. 18, 2006; revised Oct. 24, 2006; accepted Oct. 31, 2006.

Correspondence should be addressed to David A. Feldheim, University of California Santa Cruz, 428 Sinsheimer Laboratories, Santa Cruz, CA 95064. Email: Feldheim{at}biology.ucsc.edu

This article has been cited by other articles:

				J.-W. Yang, I. L. Hanganu-Opatz, J.-J. Sun, and H. J. Luhmann Three Patterns of Oscillatory Activity Differentially Synchronize Developing Neocortical Networks In Vivo J. Neurosci., July 15, 2009; 29(28): 9011 - 9025. [Abstract] [Full Text] [PDF]

				J. Cang, L. Wang, M. P. Stryker, and D. A. Feldheim Roles of Ephrin-As and Structured Activity in the Development of Functional Maps in the Superior Colliculus J. Neurosci., October 22, 2008; 28(43): 11015 - 11023. [Abstract] [Full Text] [PDF]

				Y. Hayano and N. Yamamoto Activity-Dependent Thalamocortical Axon Branching Neuroscientist, August 1, 2008; 14(4): 359 - 368. [Abstract] [PDF]

				D. J. Haustead, S. S. Lukehurst, G. T. Clutton, C. A. Bartlett, S. A. Dunlop, C. A. Arrese, R. M. Sherrard, and J. Rodger Functional Topography and Integration of the Contralateral and Ipsilateral Retinocollicular Projections of Ephrin-A-/- Mice J. Neurosci., July 16, 2008; 28(29): 7376 - 7386. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help