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The Journal of Neuroscience, December 20, 2006, 26(51):13273-13278; doi:10.1523/JNEUROSCI.4162-06.2006

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Brief Communications
Molecular Interaction between Projection Neuron Precursors and Invading Interneurons via Stromal-Derived Factor 1 (CXCL12)/CXCR4 Signaling in the Cortical Subventricular Zone/Intermediate Zone

Marie-Catherine Tiveron,¹ Mireille Rossel,² Barbara Moepps,³ Yong Li Zhang,¹ Ralph Seidenfaden,¹ Jack Favor,⁴ Norbert König,² and Harold Cremer¹

¹Institut de Biologie du Développement de Marseille Luminy, Centre National de la Recherche Scientifique/Université de Mediterranée, 13288 Marseille, France, ²EPHE, Biologie Cellulaire Quantitative, Université Montpellier 2, Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe Mixte INSERM 343, 34095 Montpellier, France, ³Department of Pharmacology and Toxicology, University of Ulm, 89081 Ulm, Germany, and ⁴Gesellschaft für Strahlung und Umweltforschung, 85764 Neuherberg, Germany

Correspondence should be addressed to either of the following: Dr. Harold Cremer, Developmental Biology Institute of Marseille Luminy, Campus de Luminy case 907, 13288 Marseille cedex 9, France, Email: cremer{at}ibdm.univ-mrs.fr; Dr. Norbert König, University Montpellier 2, CC 103, Place E. Bataillon, 34095 Montpellier cedex 5, France, Email: koenig{at}univ-montp2.fr

Most cortical interneurons are generated in the subpallial ganglionic eminences and migrate tangentially to their final destinations in the neocortex. Within the cortex, interneurons follow mainly stereotype routes in the subventricular zone/intermediate zone (SVZ/IZ) and in the marginal zone. It has been suggested that interactions between invading interneurons and locally generated projection neurons are implicated in the temporal and spatial regulation of the invasion process. However, so far experimental evidence for such interactions is lacking.

We show here that the chemokine stromal-derived factor 1 (SDF-1; CXCL12) is expressed in the main invasion route for cortical interneurons in the SVZ/IZ. Most SDF-1-positive cells are proliferating and express the homeodomain transcription factors Cux1 and Cux2. Using MASH-1 mutant mice in concert with the interneuron marker DLX, we exclude that interneurons themselves produce the chemokine in an autocrine manner. We conclude that the SDF-1-expressing cell population represents the precursors of projection neurons during their transition and amplification in the SVZ/IZ. Using mice lacking the SDF-1 receptor CXCR4 or Pax6, we demonstrate that SDF-1 expression in the cortical SVZ/IZ is essential for recognition of this pathway by interneurons. These results represent the first evidence for a molecular interaction between precursors of projection neurons and invading interneurons during corticogenesis.

Key words: neocortex; migration; tangential; Cux1; Cux2; pallium; subpallium

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Received June 14, 2006; revised Nov. 7, 2006; accepted Nov. 9, 2006.

Correspondence should be addressed to either of the following: Dr. Harold Cremer, Developmental Biology Institute of Marseille Luminy, Campus de Luminy case 907, 13288 Marseille cedex 9, France, Email: cremer{at}ibdm.univ-mrs.fr; Dr. Norbert König, University Montpellier 2, CC 103, Place E. Bataillon, 34095 Montpellier cedex 5, France, Email: koenig{at}univ-montp2.fr

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