QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, December 27, 2006, 26(52):13474-13484; doi:10.1523/JNEUROSCI.4333-06.2006

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Rabinowitch, I. Articles by Segev, I. Search for Related Content PubMed PubMed Citation Articles by Rabinowitch, I. Articles by Segev, I.

 Previous Article  |  Next Article 

Cellular/Molecular
The Endurance and Selectivity of Spatial Patterns of Long-Term Potentiation/Depression in Dendrites under Homeostatic Synaptic Plasticity

Ithai Rabinowitch and Idan Segev

Interdisciplinary Center for Neural Computation and the Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond Safra Campus, Givat Ram, Jerusalem, 91904, Israel

Correspondence should be addressed to Idan Segev, Interdisciplinary Center for Neural Computation and the Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond Safra Campus, Givat Ram, Jerusalem, 91904, Israel. Email: idan{at}lobster.ls.huji.ac.il

We investigated analytically and numerically the interplay between two opposing forms of synaptic plasticity: positive-feedback, long-term potentiation/depression (LTP/LTD), and negative-feedback, homeostatic synaptic plasticity (HSP). A detailed model of a CA1 pyramidal neuron, with numerous HSP-modifiable dendritic synapses, demonstrates that HSP may have an important role in selecting which spatial patterns of LTP/LTD are to last. Several measures are developed for predicting the net residual potentiation/depression after HSP from the initial spatial pattern of LTP/LTD. Under a local dendritic HSP mechanism, sparse patterns of LTP/LTD, which we show, using information theoretical tools, to have a significant impact on the output of the postsynaptic neuron, will persist. In contrast, spatially clustered patterns with a smaller impact on the output will diminish. A global somatic HSP mechanism, conversely, will favor distally occurring LTP/LTDs over proximal ones. Despite the negative-feedback nature of HSP, under both local and global HSP, numerous synaptic potentiations/depressions can persist. These experimentally testable results imply that HSP could be significantly involved in shaping the spatial distribution of synaptic weights in the dendrites and not just normalizing it, as is currently believed.

Key words: homeostatic plasticity; LTP; long-term potentiation; synaptic scaling; compartmental model; CA1 pyramidal; dendrite

---

Received April 5, 2005; revised Nov. 5, 2006; accepted Nov. 6, 2006.

Correspondence should be addressed to Idan Segev, Interdisciplinary Center for Neural Computation and the Department of Neurobiology, Institute of Life Sciences, The Hebrew University of Jerusalem, Edmond Safra Campus, Givat Ram, Jerusalem, 91904, Israel. Email: idan{at}lobster.ls.huji.ac.il

This article has been cited by other articles:

				P. J. Sjostrom, E. A. Rancz, A. Roth, and M. Hausser Dendritic Excitability and Synaptic Plasticity Physiol Rev, April 1, 2008; 88(2): 769 - 840. [Abstract] [Full Text] [PDF]

				F. Frohlich, M. Bazhenov, and T. J. Sejnowski Pathological Effect of Homeostatic Synaptic Scaling on Network Dynamics in Diseases of the Cortex J. Neurosci., February 13, 2008; 28(7): 1709 - 1720. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help