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The Journal of Neuroscience, December 27, 2006, 26(52):13515-13522; doi:10.1523/JNEUROSCI.4243-06.2006
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Behavioral/Systems/Cognitive
An Oculomotor Decision Process Revealed by Functional Magnetic Resonance Imaging
Stephen J. Heinen, Jess Rowland, Byeong-Taek Lee, andAlex R. Wade The Smith-Kettlewell Eye Research Institute, San Francisco, California 94115
Correspondence should be addressed to Dr. Stephen J. Heinen, Senior Scientist, The Smith-Kettlewell Eye Research Institute, 2318 Fillmore Street, San Francisco, CA 94115. Email: heinen{at}ski.org
It is not known how the brain decides to act on moving objects. We demonstrated previously that neurons in the macaque supplementary eye field (SEF) reflect the rule of ocular baseball, a go/nogo task in which eye movements signal the rule-guided interpretation of the trajectory of a target. In ocular baseball, subjects must decide whether to pursue a moving spot target with an eye movement after discriminating whether the target will cross a distal, visible line segment. Here we identify cortical regions active during the ocular baseball task using event-related human functional magnetic resonance imaging (fMRI) and concurrent eye-movement monitoring. Task-related activity was observed in the SEF, the frontal eye field (FEF), the superior parietal lobule (SPL), and the right ventrolateral prefrontal cortex (VLPFC). The SPL and right VLPFC showed heightened activity only during ocular baseball, despite identical stimuli and oculomotor demands in the control task, implicating these areas in the decision process. Furthermore, the right VLPFC but not the SPL showed the greatest activation during the nogo decision trials. This suggests both a functional dissociation between these areas and a role for the right VLPFC in rule-guided inhibition of behavior. In the SEF and FEF, activity was similar for ocular baseball and a control eye-movement task. We propose that, although the SEF reflects the ocular baseball rule, both areas in humans are functionally closer to motor processing than the SPL and the right VLPFC. By recording population activity with fMRI during the ocular baseball task, we have revealed the cortical substrate of an oculomotor decision process.
Key words: smooth pursuit; eye movements; supplementary eye fields; frontal eye fields; ventrolateral prefrontal cortex; superior parietal lobule
Received June 1, 2006; revised Nov. 21, 2006; accepted Nov. 22, 2006.
Correspondence should be addressed to Dr. Stephen J. Heinen, Senior Scientist, The Smith-Kettlewell Eye Research Institute, 2318 Fillmore Street, San Francisco, CA 94115. Email: heinen{at}ski.org
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