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The Journal of Neuroscience, March 1, 2006, 26(9):2583-2589; doi:10.1523/JNEUROSCI.4279-05.2006

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Behavioral/Systems/Cognitive
A Role for the Periaqueductal Gray in Switching Adaptive Behavioral Responses

M. H. Sukikara,¹ S. R. Mota-Ortiz,² M. V. Baldo,³ L. F. Felício,¹ and N. S. Canteras²

¹Department of Pathology, School of Veterinary Medicine, and ²Departments of Anatomy and ³Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, CEP 05508-900 São Paulo, Brazil

Correspondence should be addressed to Dr. Newton Sabino Canteras, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Avenida Lineu Prestes, 2415, CEP 05508-900 São Paulo, SP, Brazil. Email: newton{at}icb.usp.br

Previous studies suggested a role for the rostral lateral periaqueductal gray (PAG) in the inhibition of maternal behavior induced by low doses of morphine in dams with previous morphine experience. In the present study, we first showed that unilateral NMDA lesions placed in this particular PAG region prevented the morphine-induced inhibition of maternal behavior in previously morphine-sensitized dams. As suggested by previous Fos data on the PAG, predatory hunting appears as a likely candidate to replace maternal behavior in the morphine-treated dams. By testing saline- and morphine-treated dams with live cockroaches only, we have presently shown that morphine challenge increased insect hunting. Moreover, morphine- and saline-treated dams were also observed in an environment containing pups and roaches. Although most of the saline-treated animals displayed active nursing and only occasionally presented insect hunting, all of the morphine-treated animals ignored the pups and avidly pursued and caught the roaches. We next questioned whether the rostral lateral PAG would be involved in this behavioral switch. Our results showed that unilateral lesions of the rostral lateral PAG, but not other parts of the PAG, partially impaired predatory hunting and restored part of the maternal response. Moreover, bilateral lesions of the rostral lateral PAG produced even more dramatic effects in inhibiting insect hunting and restoring maternal behavior. The present findings indisputably show that the rostral lateral PAG influences switching from maternal to hunting behavior in morphine-treated dams, thus supporting a previously unsuspected role for the PAG in selecting adaptive behavioral responses.

Key words: periaqueductal gray; maternal behavior; predatory hunting; behavioral selection; NMDA lesion; morphine

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Received Oct. 7, 2005; revised Jan. 18, 2006; accepted Jan. 22, 2006.

Correspondence should be addressed to Dr. Newton Sabino Canteras, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Avenida Lineu Prestes, 2415, CEP 05508-900 São Paulo, SP, Brazil. Email: newton{at}icb.usp.br

This article has been cited by other articles:

				M. Numan Hypothalamic neural circuits regulating maternal responsiveness toward infants. Behav Cogn Neurosci Rev, December 1, 2006; 5(4): 163 - 190. [Abstract] [PDF]

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