QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, January 3, 2007, 27(1):132-140; doi:10.1523/JNEUROSCI.2439-06.2007

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by De Saint Jan, D. Articles by Westbrook, G. L. Search for Related Content PubMed PubMed Citation Articles by De Saint Jan, D. Articles by Westbrook, G. L.

 Previous Article  |  Next Article 

Cellular/Molecular
Disynaptic Amplification of Metabotropic Glutamate Receptor 1 Responses in the Olfactory Bulb

Didier De Saint Jan and Gary L. Westbrook

Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239

Correspondence should be addressed to Dr. Didier De Saint Jan, Institut National de la Santé et de la Recherche Médicale U603, 45 rue des Saints Pères, 75006 Paris, France. Email: didier.desaintjan{at}univ-paris5.fr

Sensory systems often respond to rapid stimuli with high frequency and fidelity, as perhaps best exemplified in the auditory system. Fast synaptic responses are fundamental requirements to achieve this task. The importance of speed is less clear in the olfactory system. Moreover, olfactory bulb output mitral cells respond to a single stimulation of the sensory afferents with unusually long EPSPs, lasting several seconds. We examined the temporal characteristics, developmental regulation, and the mechanism generating these responses in mouse olfactory bulb slices. The slow EPSP appeared at postnatal days 10–11 and was mediated by metabotropic glutamate receptor 1 (mGluR1) and NMDA receptors. mGluR1 contribution was unexpected because its activation usually requires strong, high-frequency stimulation of inputs. However, dendritic release of glutamate from the intraglomerular network caused spillover-mediated recurrent activation of metabotropic glutamate receptors. We suggest that persistent responses in mitral cells amplify the incoming sensory information and, along with asynchronous inputs, drive odor-evoked slow temporal activity in the bulb.

Key words: mGluR; olfactory bulb; mitral cell; glutamate spillover; glomerulus; synaptic transmission

---

Received June 8, 2006; revised Oct. 20, 2006; accepted Nov. 27, 2006.

Correspondence should be addressed to Dr. Didier De Saint Jan, Institut National de la Santé et de la Recherche Médicale U603, 45 rue des Saints Pères, 75006 Paris, France. Email: didier.desaintjan{at}univ-paris5.fr

This article has been cited by other articles:

				D. H. Gire and N. E. Schoppa Control of On/Off Glomerular Signaling by a Local GABAergic Microcircuit in the Olfactory Bulb J. Neurosci., October 28, 2009; 29(43): 13454 - 13464. [Abstract] [Full Text] [PDF]

				H.-W. Dong, A. Hayar, J. Callaway, X.-H. Yang, Q. Nai, and M. Ennis Group I mGluR Activation Enhances Ca2+-Dependent Nonselective Cation Currents and Rhythmic Bursting in Main Olfactory Bulb External Tufted Cells J. Neurosci., September 23, 2009; 29(38): 11943 - 11953. [Abstract] [Full Text] [PDF]

				H. Matsumoto, H. Kashiwadani, H. Nagao, A. Aiba, and K. Mori Odor-Induced Persistent Discharge of Mitral Cells in the Mouse Olfactory Bulb J Neurophysiol, April 1, 2009; 101(4): 1890 - 1900. [Abstract] [Full Text] [PDF]

				Z. Shao, A. C. Puche, E. Kiyokage, G. Szabo, and M. T. Shipley Two GABAergic Intraglomerular Circuits Differentially Regulate Tonic and Phasic Presynaptic Inhibition of Olfactory Nerve Terminals J Neurophysiol, April 1, 2009; 101(4): 1988 - 2001. [Abstract] [Full Text] [PDF]

				D. De Saint Jan, D. Hirnet, G. L. Westbrook, and S. Charpak External Tufted Cells Drive the Output of Olfactory Bulb Glomeruli J. Neurosci., February 18, 2009; 29(7): 2043 - 2052. [Abstract] [Full Text] [PDF]

				W. J. Tyler, G. C. Petzold, S. K. Pal, and V. N. Murthy Experience-Dependent Modification of Primary Sensory Synapses in the Mammalian Olfactory Bulb J. Neurosci., August 29, 2007; 27(35): 9427 - 9438. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help