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The Journal of Neuroscience, March 7, 2007, 27(10):2683-2692; doi:10.1523/JNEUROSCI.5077-06.2007

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Behavioral/Systems/Cognitive
Transmission of Spike Trains at the Retinogeniculate Synapse

Lawrence C. Sincich, Daniel L. Adams, John R. Economides, and Jonathan C. Horton

Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143

Correspondence should be addressed to Dr. Lawrence C. Sincich, Beckman Vision Center, 10 Koret Way, University of California, San Francisco, San Francisco, CA 94143-0730. Email: sincichl{at}vision.ucsf.edu

Retinal spikes impinging on relay neurons in the lateral geniculate nucleus (LGN) generate synaptic potentials, which sometimes produce spikes sent to visual cortex. We examined how signal transmission is regulated in the macaque LGN by recording the retinal input to a single LGN neuron while stimulating the receptive field center with a naturalistic luminance sequence. After extracting the EPSPs, which are often partially merged with spike waveforms, we found that >95% of spikes were associated with an EPSP from a single retinal ganglion cell. Each spike within a "burst" train was generated by an EPSP, indicating that LGN bursts are inherited from retinal bursts. LGN neurons rarely fired unless at least two EPSPs summated within 40 ms. This facilitation in EPSP efficacy was followed by depression. If a spike was generated by the first EPSP in a pair, it did not alter the efficacy of the second EPSP. Hence, the timing of EPSPs arising from the primary retinal driver governs synaptic efficacy and provides the basis for successful retinogeniculate transmission.

Key words: retinal ganglion cells; lateral geniculate nucleus; luminance; natural statistics; spike generation; S-potential; neural coding; T-type calcium current

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Received Nov. 22, 2006; revised Jan. 13, 2007; accepted Jan. 15, 2007.

Correspondence should be addressed to Dr. Lawrence C. Sincich, Beckman Vision Center, 10 Koret Way, University of California, San Francisco, San Francisco, CA 94143-0730. Email: sincichl{at}vision.ucsf.edu

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