QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, March 7, 2007, 27(10):2704-2717; doi:10.1523/JNEUROSCI.2991-06.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (22) Citing Articles via Google Scholar Google Scholar Articles by Belvindrah, R. Articles by Müller, U. Search for Related Content PubMed PubMed Citation Articles by Belvindrah, R. Articles by Müller, U.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
ß1 Integrins Control the Formation of Cell Chains in the Adult Rostral Migratory Stream

Richard Belvindrah,¹ Sabine Hankel,¹ John Walker,² Bruce L. Patton,³ and Ulrich Müller¹

¹The Scripps Research Institute, Department of Cell Biology, Institute for Childhood and Neglected Disease, La Jolla, California 92037, ²Genomic Institute of the Novartis Research Foundation, San Diego, California 92121, and ³Oregon Health and Science University, Portland, Oregon 97239

Correspondence should be addressed to Ulrich Müller, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92073. Email: umueller{at}scripps.edu

The subventricular zone (SVZ) of the lateral ventricle is the major site of neurogenesis in the adult brain. Neuroblasts that are born in the SVZ migrate as chains along the rostral migratory stream (RMS) to the olfactory bulb. Little is known about the mechanisms that control interactions between neuroblasts during their migration. Here we show that migrating neuroblasts express ß1integrins and that the integrin ligand laminin is localized to cell chains. Using genetically modified mice and time-lapse video recordings of SVZ explants, we demonstrate that ß1 integrins and laminin promote the formation of cell chains. Laminin also induces the aggregation of purified neuroblasts. We conclude that the formation of cell chains in the RMS is controlled in part by ß1 integrins via binding to laminin. In addition, we provide evidence that ß1 class integrins are required for the maintenance of the glial tubes and that defects in the glial tubes lead to the ectopic migration of neuroblasts into the surrounding tissue.

Key words: ß1 integrins; SVZ; RMS; migration; laminin; CNS

---

Received July 14, 2006; revised Jan. 26, 2007; accepted Jan. 29, 2007.

Correspondence should be addressed to Ulrich Müller, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92073. Email: umueller{at}scripps.edu

This article has been cited by other articles:

				A. K. Mobley, J. H. Tchaicha, J. Shin, M. G. Hossain, and J. H. McCarty {beta}8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain J. Cell Sci., June 1, 2009; 122(11): 1842 - 1851. [Abstract] [Full Text] [PDF]

				M. Snapyan, M. Lemasson, M. S. Brill, M. Blais, M. Massouh, J. Ninkovic, C. Gravel, F. Berthod, M. Gotz, P. A. Barker, et al. Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling J. Neurosci., April 1, 2009; 29(13): 4172 - 4188. [Abstract] [Full Text] [PDF]

				J. J. Ohab and S. T. Carmichael Poststroke Neurogenesis: Emerging Principles of Migration and Localization of Immature Neurons Neuroscientist, August 1, 2008; 14(4): 369 - 380. [Abstract] [PDF]

				D. Garzotto, P. Giacobini, T. Crepaldi, A. Fasolo, and S. De Marchis Hepatocyte Growth Factor Regulates Migration of Olfactory Interneuron Precursors in the Rostral Migratory Stream through Met-Grb2 Coupling J. Neurosci., June 4, 2008; 28(23): 5901 - 5909. [Abstract] [Full Text] [PDF]

				Y. Hirota, T. Ohshima, N. Kaneko, M. Ikeda, T. Iwasato, A. B. Kulkarni, K. Mikoshiba, H. Okano, and K. Sawamoto Cyclin-Dependent Kinase 5 Is Required for Control of Neuroblast Migration in the Postnatal Subventricular Zone J. Neurosci., November 21, 2007; 27(47): 12829 - 12838. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help