QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, March 14, 2007, 27(11):2788-2792; doi:10.1523/JNEUROSCI.5013-06.2007

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Miskowiak, K. Articles by Harmer, C. J. Search for Related Content PubMed PubMed Citation Articles by Miskowiak, K. Articles by Harmer, C. J. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Medline Plus Health Information Memory

 Previous Article  |  Next Article 

Brief Communications
Erythropoietin Enhances Hippocampal Response during Memory Retrieval in Humans

Kamilla Miskowiak,^1,2 Ursula O'Sullivan,² and Catherine J. Harmer^1,2

¹Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom, and ²Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom

Correspondence should be addressed to Kamilla Miskowiak, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK. Email: kamilla.miskowiak{at}psy.ox.ac.uk

Although erythropoietin (Epo) is best known for its effects on erythropoiesis, recent evidence suggests that it also has neurotrophic and neuroprotective properties in animal models of hippocampal function. Such an action in humans would make it an intriguing novel compound for the treatment of neurological and psychiatric disorders. The current study therefore aimed to explore the effects of Epo on neural and behavioral measures of hippocampal function in humans using a functional magnetic resonance imaging paradigm. Volunteers were randomized to receive intravenous injection of Epo (40,000 IU) or saline in a between-subjects, double-blind, randomized design. Neural response during picture encoding and retrieval was tested 1 week later. Epo increased hippocampus response during picture retrieval (n = 11) compared with placebo (n = 12; p = 0.04) independent of changes in hematocrit. This is consistent with upregulation of hippocampal BDNF and neurotrophic actions found in animals and highlights Epo as a promising candidate for treatment of psychiatric disorders.

Key words: erythropoietin; hippocampal function; cognitive; fMRI; human; neurogenesis

---

Received Nov. 18, 2006; revised Jan. 15, 2007; accepted Jan. 30, 2007.

Correspondence should be addressed to Kamilla Miskowiak, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK. Email: kamilla.miskowiak{at}psy.ox.ac.uk

This article has been cited by other articles:

				M. Brines, N. S. A. Patel, P. Villa, C. Brines, T. Mennini, M. De Paola, Z. Erbayraktar, S. Erbayraktar, B. Sepodes, C. Thiemermann, et al. Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin PNAS, August 5, 2008; 105(31): 10925 - 10930. [Abstract] [Full Text] [PDF]

				P. Bekinschtein, M. Cammarota, I. Izquierdo, and J. H. Medina Reviews: BDNF and Memory Formation and Storage Neuroscientist, April 1, 2008; 14(2): 147 - 156. [Abstract] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help