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The Journal of Neuroscience, March 14, 2007, 27(11):3010-3016; doi:10.1523/JNEUROSCI.5051-06.2007

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Behavioral/Systems/Cognitive
Neural Changes in Control Implementation of a Continuous Task

Ovidiu V. Lungu,1,2 Meagan M. Binenstock,3 Megan A. Pline,3 Jennifer R. Yeaton,3 and James R. Carey3

1Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, and 2Departments of Neuroscience and 3Physical Therapy, University of Minnesota, Minneapolis, Minnesota 55455

Correspondence should be addressed to Dr. Ovidiu V. Lungu, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Université de Montréal, Room M-6814, 4565 Chemin Queen Mary, Montreal, Quebec, Canada H3W 1W5. Email: Ovidiu.Lungu{at}criugm.rtss.qc.ca

It is commonly agreed that control implementation, being a resource-consuming endeavor, is not exerted continuously or in simple tasks. However, most research in the field was done using tasks that varied the need for control on a trial-by-trial basis (e.g., Stroop, flanker) in a discrete manner. In this case, the anterior cingulate cortex (ACC) was found to monitor the need for control, whereas regions in the prefrontal cortex (PFC) were found to be involved in control implementation. Whether or not the same control mechanism would be used in continuous tasks was an open question. In our study, we found that in a continuous task, the same neural substrate subserves control monitoring (ACC) but that the neural substrate of control implementation changes over time. Early in the task, regions in the PFC were involved in control implementation, whereas later the control was taken over by subcortical structures, specifically the caudate. Our results suggest that humans possess a flexible control mechanism, with a specific structure dedicated to monitoring the need for control and with multiple structures involved in control implementation.

Key words: fMRI; cognitive control; ACC; DLPFC; caudate; adaptation

Received Nov. 21, 2006; revised Jan. 9, 2007; accepted Feb. 5, 2007.

Correspondence should be addressed to Dr. Ovidiu V. Lungu, Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Université de Montréal, Room M-6814, 4565 Chemin Queen Mary, Montreal, Quebec, Canada H3W 1W5. Email: Ovidiu.Lungu{at}criugm.rtss.qc.ca






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