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The Journal of Neuroscience, March 21, 2007, 27(12):3211-3229; doi:10.1523/JNEUROSCI.4724-06.2007
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Behavioral/Systems/Cognitive
Scale-Invariant Memory Representations Emerge from Moiré Interference between Grid Fields That Produce Theta Oscillations: A Computational Model
Hugh T. Blair,1 Adam C. Welday,1 andKechen Zhang2 1University of California, Los Angeles Psychology Department, Los Angeles, California 90095, and 2Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Correspondence should be addressed to Dr. Hugh T. Blair, University of California, Los Angeles Psychology Department, 1285 Franz Hall, Los Angeles, CA 90095-1563. Email: blair{at}psych.ucla.edu
The dorsomedial entorhinal cortex (dMEC) of the rat brain contains a remarkable population of spatially tuned neurons called grid cells (Hafting et al., 2005). Each grid cell fires selectively at multiple spatial locations, which are geometrically arranged to form a hexagonal lattice that tiles the surface of the rat's environment. Here, we show that grid fields can combine with one another to form moiré interference patterns, referred to as "moiré grids," that replicate the hexagonal lattice over an infinite range of spatial scales. We propose that dMEC grids are actually moiré grids formed by interference between much smaller "theta grids," which are hypothesized to be the primary source of movement-related theta rhythm in the rat brain. The formation of moiré grids from theta grids obeys two scaling laws, referred to as the length and rotational scaling rules. The length scaling rule appears to account for firing properties of grid cells in layer II of dMEC, whereas the rotational scaling rule can better explain properties of layer III grid cells. Moiré grids built from theta grids can be combined to form yet larger grids and can also be used as basis functions to construct memory representations of spatial locations (place cells) or visual images. Memory representations built from moiré grids are automatically endowed with size invariance by the scaling properties of the moiré grids. We therefore propose that moiré interference between grid fields may constitute an important principle of neural computation underlying the construction of scale-invariant memory representations.
Key words: hippocampus; place cell; entorhinal cortex; grid cells; theta rhythm; recognition memory
Received July 13, 2006; revised Feb. 12, 2007; accepted Feb. 12, 2007.
Correspondence should be addressed to Dr. Hugh T. Blair, University of California, Los Angeles Psychology Department, 1285 Franz Hall, Los Angeles, CA 90095-1563. Email: blair{at}psych.ucla.edu
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