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The Journal of Neuroscience, March 21, 2007, 27(12):3285-3294; doi:10.1523/JNEUROSCI.5202-06.2007

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Behavioral/Systems/Cognitive
Segment Specificity of Load Signal Processing Depends on Walking Direction in the Stick Insect Leg Muscle Control System

Turgay Akay,¹ Björn Ch. Ludwar,¹ Marie L. Göritz,¹ Josef Schmitz,² and Ansgar Büschges¹

¹Department of Animal Physiology, Zoological Institute, University of Cologne, 50923 Cologne, Germany, and ²Department of Biological Cybernetics, Faculty of Biology, University of Bielefeld, 33501 Bielefeld, Germany

Correspondence should be addressed to Dr. Ansgar Büschges, Zoological Institute, University of Cologne, Weyertal 119, 50923 Cologne, Germany. Email: ansgar.bueschges{at}uni-koeln.de

In terrestrial locomotion, sensory feedback from load sensors is important for altering ongoing motor output on a step-by-step basis. We investigated the influence of load signals from the leg on motoneuron pools of the thorax-coxa (ThC) joint in the stick insect walking system. Load sensors were stimulated during rhythmic, alternating activity in protractor coxae (ProCx) and retractor coxae (RetCx) motoneuron pools. Alternating activity in the segment of interest was induced by mechanical stimulation of the animal or pharmacological activation of the isolated thoracic ganglia. Load signals from the legs altered the timing of ThC motoneuron activity by resetting and entraining the activity of the central rhythm generating network of the ThC joint. In the front and middle legs, load signals induced or promoted RetCx activity and decreased or terminated ProCx activity. In the hindleg, reverse transitions were elicited, with increasing load terminating RetCx and initiating ProCx activity. Studies in semi-intact walking animals showed that the effect of load on the ThC-joint motoneurons depended on walking direction, with increased load promoting the functional stance phase motoneuron pool (in forward walking, RetCx activity; in backward walking, ProCx activity). Thus, we show that modifications of sensory feedback in a locomotor system are related to walking direction. In a final set of ablation experiments, we show that the load influence is mediated by the three groups of trochanteral campaniform sensilla.

Key words: walking direction; campaniform sensilla; sensory feedback; pattern generation; locomotion; reflex reversal

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Received Dec. 1, 2006; revised Feb. 14, 2007; accepted Feb. 15, 2007.

Correspondence should be addressed to Dr. Ansgar Büschges, Zoological Institute, University of Cologne, Weyertal 119, 50923 Cologne, Germany. Email: ansgar.bueschges{at}uni-koeln.de

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