 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, April 4, 2007, 27(14):3743-3752; doi:10.1523/JNEUROSCI.0519-07.2007
Previous Article | Next Article
Behavioral/Systems/Cognitive
Triangulating a Cognitive Control Network Using Diffusion-Weighted Magnetic Resonance Imaging (MRI) and Functional MRI
Adam R. Aron,1,2 Tim E. Behrens,3,4 Steve Smith,3 Michael J. Frank,5 andRussell A. Poldrack2 1Department of Psychology, University of California San Diego, La Jolla, California 92093, 2Department of Psychology and Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095, 3Center for Functional Magnetic Resonance Imaging of the Brain and 4Department of Experimental Psychology, University of Oxford, Oxford OX3 9DU, United Kingdom, and 5Department of Psychology, University of Arizona, Tucson, Arizona 85721
Correspondence should be addressed to Dr. A. R. Aron, Department of Psychology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093. Email: adamaron{at}ucsd.edu
The ability to stop motor responses depends critically on the right inferior frontal cortex (IFC) and also engages a midbrain region consistent with the subthalamic nucleus (STN). Here we used diffusion-weighted imaging (DWI) tractography to show that the IFC and the STN region are connected via a white matter tract, which could underlie a "hyperdirect" pathway for basal ganglia control. Using a novel method of "triangulation" analysis of tractography data, we also found that both the IFC and the STN region are connected with the presupplementary motor area (preSMA). We hypothesized that the preSMA could play a conflict detection/resolution role within a network between the preSMA, the IFC, and the STN region. A second experiment tested this idea with functional magnetic resonance imaging (fMRI) using a conditional stop-signal paradigm, enabling examination of behavioral and neural signatures of conflict-induced slowing. The preSMA, IFC, and STN region were significantly activated the greater the conflict-induced slowing. Activation corresponded strongly with spatial foci predicted by the DWI tract analysis, as well as with foci activated by complete response inhibition. The results illustrate how tractography can reveal connections that are verifiable with fMRI. The results also demonstrate a three-way functional–anatomical network in the right hemisphere that could either brake or completely stop responses.
Key words: cognitive control; inferior frontal cortex; presupplementary motor area; subthalamic nucleus; tractography; stop signal
Received Feb. 6, 2007; revised Feb. 22, 2007; accepted Feb. 23, 2007.
Correspondence should be addressed to Dr. A. R. Aron, Department of Psychology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093. Email: adamaron{at}ucsd.edu
Related articles in J. Neurosci.:
- This Week in The Journal
J. Neurosci. 2007 27: i.[Full Text]
This article has been cited by other articles:
D. G. Ghahremani, J. Monterosso, J. D. Jentsch, R. M. Bilder, and R. A. Poldrack
Neural Components Underlying Behavioral Flexibility in Human Reversal Learning
Cereb Cortex, November 13, 2009; (2009) bhp247v1.
[Abstract] [Full Text] [PDF]
N. Swann, N. Tandon, R. Canolty, T. M. Ellmore, L. K. McEvoy, S. Dreyer, M. DiSano, and A. R. Aron
Intracranial EEG Reveals a Time- and Frequency-Specific Role for the Right Inferior Frontal Gyrus and Primary Motor Cortex in Stopping Initiated Responses
J. Neurosci., October 7, 2009; 29(40): 12675 - 12685.
[Abstract] [Full Text] [PDF]
T. Dalgleish, B. D. Dunn, and D. Mobbs
Affective Neuroscience: Past, Present, and Future
Emotion Review, October 1, 2009; 1(4): 355 - 368.
[Abstract] [PDF]
D. L. Harrington, J. L. Zimbelman, S. C. Hinton, and S. M. Rao
Neural Modulation of Temporal Encoding, Maintenance, and Decision Processes
Cereb Cortex, September 24, 2009; (2009) bhp194v1.
[Abstract] [Full Text] [PDF]
S. Galati, P. Stanzione, V. D'Angelo, E. Fedele, F. Marzetti, G. Sancesario, T. Procopio, and A. Stefani
The pharmacological blockade of medial forebrain bundle induces an acute pathological synchronization of the cortico\#8211;subthalamic nucleus\#8211;globus pallidus pathway
J. Physiol., September 15, 2009; 587(18): 4405 - 4423.
[Abstract] [Full Text] [PDF]
P. S. Lee, B. E. Yerys, A. Della Rosa, J. Foss-Feig, K. A. Barnes, J. D. James, J. VanMeter, C. J. Vaidya, W. D. Gaillard, and L. E. Kenworthy
Functional Connectivity of the Inferior Frontal Cortex Changes with Age in Children with Autism Spectrum Disorders: A fcMRI Study of Response Inhibition
Cereb Cortex, August 1, 2009; 19(8): 1787 - 1794.
[Abstract] [Full Text] [PDF]
C. N. Boehler, T. F. Munte, R. M. Krebs, H. -J. Heinze, M. A. Schoenfeld, and J. -M. Hopf
Sensory MEG Responses Predict Successful and Failed Inhibition in a Stop-Signal Task
Cereb Cortex, January 1, 2009; 19(1): 134 - 145.
[Abstract] [Full Text] [PDF]
D. M. Barch, T. S. Braver, C. S. Carter, R. A. Poldrack, and T. W. Robbins
CNTRICS Final Task Selection: Executive Control
Schizophr Bull, January 1, 2009; 35(1): 115 - 135.
[Abstract] [Full Text] [PDF]
G. Xue, D. G. Ghahremani, and R. A. Poldrack
Neural Substrates for Reversing Stimulus-Outcome and Stimulus-Response Associations
J. Neurosci., October 29, 2008; 28(44): 11196 - 11204.
[Abstract] [Full Text] [PDF]
B. U. Forstmann, S. Jahfari, H. S. Scholte, U. Wolfensteller, W. P. M. van den Wildenberg, and K. R. Ridderinkhof
Function and Structure of the Right Inferior Frontal Cortex Predict Individual Differences in Response Inhibition: A Model-Based Approach
J. Neurosci., September 24, 2008; 28(39): 9790 - 9796.
[Abstract] [Full Text] [PDF]
G. Xue, A. R. Aron, and R. A. Poldrack
Common Neural Substrates for Inhibition of Spoken and Manual Responses
Cereb Cortex, August 1, 2008; 18(8): 1923 - 1932.
[Abstract] [Full Text] [PDF]
M. Isoda and O. Hikosaka
Role for Subthalamic Nucleus Neurons in Switching from Automatic to Controlled Eye Movement
J. Neurosci., July 9, 2008; 28(28): 7209 - 7218.
[Abstract] [Full Text] [PDF]
C. L. Baym, B. A. Corbett, S. B. Wright, and S. A. Bunge
Neural correlates of tic severity and cognitive control in children with Tourette syndrome
Brain, January 1, 2008; 131(1): 165 - 179.
[Abstract] [Full Text] [PDF]
G. Mirabella
Endogenous Inhibition and the Neural Basis of "Free Won't"
J. Neurosci., December 19, 2007; 27(51): 13919 - 13920.
[Full Text] [PDF]
C. D. Chambers, M. A. Bellgrove, I. C. Gould, T. English, H. Garavan, E. McNaught, M. Kamke, and J. B. Mattingley
Dissociable Mechanisms of Cognitive Control in Prefrontal and Premotor Cortex
J Neurophysiol, December 1, 2007; 98(6): 3638 - 3647.
[Abstract] [Full Text] [PDF]
M. J. Frank, J. Samanta, A. A. Moustafa, and S. J. Sherman
Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism
Science, November 23, 2007; 318(5854): 1309 - 1312.
[Abstract] [Full Text] [PDF]
A. R. Aron, S. Durston, D. M. Eagle, G. D. Logan, C. M. Stinear, and V. Stuphorn
Converging Evidence for a Fronto-Basal-Ganglia Network for Inhibitory Control of Action and Cognition
J. Neurosci., October 31, 2007; 27(44): 11860 - 11864.
[Full Text] [PDF]
V. Tomassini, S. Jbabdi, J. C. Klein, T. E. J. Behrens, C. Pozzilli, P. M. Matthews, M. F. S. Rushworth, and H. Johansen-Berg
Diffusion-Weighted Imaging Tractography-Based Parcellation of the Human Lateral Premotor Cortex Identifies Dorsal and Ventral Subregions with Anatomical and Functional Specializations
J. Neurosci., September 19, 2007; 27(38): 10259 - 10269.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|