QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, April 11, 2007, 27(15):4061-4071; doi:10.1523/JNEUROSCI.0068-07.2007

This Article Full Text Full Text (PDF) A correction has been published Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Apergis-Schoute, J. Articles by Paré, D. Search for Related Content PubMed PubMed Citation Articles by Apergis-Schoute, J. Articles by Paré, D. Pubmed/NCBI databases Compound via MeSH Substance via MeSH

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Muscarinic Control of Long-Range GABAergic Inhibition within the Rhinal Cortices

John Apergis-Schoute, Aline Pinto, and Denis Paré

Center for Molecular and Behavioral Neuroscience, Rutgers University, The State University of New Jersey, Newark, New Jersey 07102

Correspondence should be addressed to Denis Paré, Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Avenue, Newark, NJ 07102. Email: pare{at}axon.rutgers.edu

The perirhinal cortex plays a critical role in memory formation, in part because it forms reciprocal connections with the neocortex and entorhinal cortex and is thus in a position to integrate and transfer higher-order information to and from the hippocampus. However, for reasons that remain unclear, perirhinal transfer of neocortical inputs to the entorhinal cortex occurs with a low probability. Using patch recordings in vitro and tract-tracing combined with GAD-67 immunohistochemistry, we show that the perirhinal cortex contains GABAergic neurons with long-range projections to superficial entorhinal cells. This finding challenges the traditional model of cortical inhibition in which all trans-areal inhibition is thought to be disynaptic because the axons of GABAergic interneurons are assumed to be confined within the area in which their somata are located. Moreover, consistent with recent studies indicating that the formation of perirhinal-dependent memories requires activation of muscarinic receptors, long-range IPSPs were presynaptically inhibited by M₂ receptor activation. Overall, these results suggest that long-range feedforward inhibition regulates perirhinal transfer of neocortical inputs to the entorhinal cortex, but that cholinergic inputs can presynaptically adjust the impact of this control mechanism as a function of environmental contingencies.

Key words: perirhinal; entorhinal; hippocampus; inhibition; interneurons; learning; memory

---

Received Nov. 7, 2006; revised Feb. 22, 2007; accepted Feb. 24, 2007.

Correspondence should be addressed to Denis Paré, Center for Molecular and Behavioral Neuroscience, Rutgers State University, 197 University Avenue, Newark, NJ 07102. Email: pare{at}axon.rutgers.edu

This article has been cited by other articles:

				R. Paz, E. P. Bauer, and D. Pare Theta synchronizes the activity of medial prefrontal neurons during learning Learn. Mem., July 8, 2008; 15(7): 524 - 531. [Abstract] [Full Text] [PDF]

				S. Jinno, T. Klausberger, L. F. Marton, Y. Dalezios, J. D. B. Roberts, P. Fuentealba, E. A. Bushong, D. Henze, G. Buzsaki, and P. Somogyi Neuronal Diversity in GABAergic Long-Range Projections from the Hippocampus J. Neurosci., August 15, 2007; 27(33): 8790 - 8804. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help