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The Journal of Neuroscience, April 18, 2007, 27(16):4297-4302; doi:10.1523/JNEUROSCI.0399-07.2007

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Brief Communications
Dorsal Radial Glia Generate Olfactory Bulb Interneurons in the Postnatal Murine Brain

Rachel E. Ventura¹ and James E. Goldman^1,2

¹Center for Neurobiology and Behavior and ²Department of Pathology, Columbia University, New York, New York 10032

Correspondence should be addressed to James E. Goldman, P&S 15-420, 630 West 168th Street, New York, NY 10032. Email: jeg5{at}columbia.edu

During embryogenesis, dorsal radial glia generate pyramidal cell neurons but not interneurons, and are thought to degenerate or transform into astrocytes in the postnatal brain. Ventral radial glia, in contrast, retract their processes to form GFAP+ subventricular zone (SVZ) astrocytes that continue to generate interneurons into adulthood. We sought to fate map dorsal radial glia by codelivering an adenovirus expressing Cre recombinase and a lentivirus expressing dsRedExpress to the dorsal cortical surface of ROSA26R-YFP mice. Whereas the adenovirus is retrogradely transported to the cell body, the VSV-G (vesicular stomatitis virus G) pseudotyped lentivirus is not and allows us to control for viral diffusion from the site of infection. We found that dorsal radial glia give rise to gray and white matter astrocytes and oligodendrocytes. In addition, the dorsal radial glia fate map to astrocytes lining the dorsal aspect of the SVZ that persist at least 8 weeks postnatally. Finally, we found that dorsal radial glial-derived cells generate granule cell and periglomerular interneurons in the olfactory bulb and continue to form interneuronal precursors into adulthood.

Key words: radial glia; subventricular zone; olfactory bulb; interneuron; dorsal; development; postnatal

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Received Jan. 29, 2007; revised March 9, 2007; accepted March 10, 2007.

Correspondence should be addressed to James E. Goldman, P&S 15-420, 630 West 168th Street, New York, NY 10032. Email: jeg5{at}columbia.edu

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