QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, April 18, 2007, 27(16):4396-4402; doi:10.1523/JNEUROSCI.4054-06.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Qian, M. Articles by Zhong, Y. Search for Related Content PubMed PubMed Citation Articles by Qian, M. Articles by Zhong, Y.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Receptor-Like Tyrosine Phosphatase PTP10D Is Required for Long-Term Memory in Drosophila

Meng Qian,^1 * Guohui Pan,^1 * Lu Sun,¹ Chunhua Feng,³ Zuoping Xie,¹ Tim Tully,² and Yi Zhong^1,2

¹Department of Biological Science and Biotechnology, Tsinghua University, Beijing, China 100084, ²Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 11724, and ³JoeKai Inc., Beijing, China 100084

Correspondence should be addressed to Yi Zhong, Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724. Email: zhongyi{at}cshl.edu

Tyrosine phosphorylation mediates multiple signal transduction pathways that play key roles in developmental processes and behavioral plasticity. The level of tyrosine phosphorylation is regulated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Extensive studies have investigated the roles of tyrosine kinases in memory formation. However, there were few studies on PTPs. To date, learning has been shown to be defective only for mouse knock-outs of PTP, leukocyte common antigen-related, or PTP. A major limitation of these studies arises from their inability to distinguish an acute (biochemical) impairment of memory formation from a more chronic abnormality in neurodevelopment. From a behavioral screen for defective long-term memory, we found chi mutants to disrupt expression of the PTP10D protein tyrosine phosphatase gene. We show that chi mutants are normal for learning, early memory, and anesthesia-resistant memory, whereas long-term memory specifically is abolished. Significantly, induction of a heat shock-PTP10D⁺ transgene before training fully rescues the memory defect of chi mutants, thereby demonstrating an acute role for PTP10D in behavioral plasticity. We show that PTP10D is widely expressed in the embryonic CNS and in the adult brain. Transgenic expression of upstream activating sequence-PTP10D⁺ in mushroom bodies is sufficient to rescue the memory defect of chi mutants. Our data clearly demonstrate that signaling through PTP10D in mushroom bodies is critical for the formation of long-term memory.

Key words: PTP10D; long-term memory; mushroom bodies; chi; behavior; screen

---

Received Sept. 16, 2006; revised Feb. 13, 2007; accepted Feb. 16, 2007.

Correspondence should be addressed to Yi Zhong, Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724. Email: zhongyi{at}cshl.edu

This article has been cited by other articles:

				M. Jeon and K. Zinn Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling Development, September 15, 2009; 136(18): 3121 - 3129. [Abstract] [Full Text] [PDF]

				H. Zhao, X. Zheng, X. Yuan, L. Wang, X. Wang, Y. Zhong, Z. Xie, and T. Tully ben Functions with Scamp during Synaptic Transmission and Long-Term Memory Formation in Drosophila J. Neurosci., January 14, 2009; 29(2): 414 - 424. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help