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The Journal of Neuroscience, April 25, 2007, 27(17):4598-4602; doi:10.1523/JNEUROSCI.0325-07.2007

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Brief Communications
Conservation of Glutamate Receptor 2-Containing AMPA Receptors during Long-Term Potentiation

Hillel Adesnik¹ and Roger A. Nicoll^1,2

Departments of ¹Cellular and Molecular Pharmacology and ²Physiology, University of California, San Francisco, San Francisco, California 94143

Correspondence should be addressed to Roger A. Nicoll, Department of Cellular and Molecular Pharmacology, University of California San Francisco, CA 94143. Email: nicoll{at}cmp.ucsf.edu

Long-term potentiation (LTP) at hippocampal synapses is thought to involve the insertion of AMPA receptors into the postsynaptic membrane. Conflicting evidence exists as to whether calcium-permeable receptors are inserted during LTP and whether synaptic activity mediated by the newly inserted AMPA receptors is required to maintain the increase in synaptic strength. Here, we rigorously test these hypotheses and conclude that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained.

Key words: activity; AMPA receptor; calcium channels; glutamate receptor; LTP (long-term potentiation); memory

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Received Jan. 30, 2007; revised March 20, 2007; accepted March 21, 2007.

Correspondence should be addressed to Roger A. Nicoll, Department of Cellular and Molecular Pharmacology, University of California San Francisco, CA 94143. Email: nicoll{at}cmp.ucsf.edu

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GluR2-lacking AMPA receptors and the expression of LTP

John T Isaac

J. Neurosci. Online, 26 May 2007 [Full text]

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