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The Journal of Neuroscience, May 2, 2007, 27(18):4902-4909; doi:10.1523/JNEUROSCI.0717-07.2007

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Development/Plasticity/Repair
Lbx1 Acts as a Selector Gene in the Fate Determination of Somatosensory and Viscerosensory Relay Neurons in the Hindbrain

Martin A. Sieber,^1 * Robert Storm,^1 * Margaret Martinez-de-la-Torre,² Thomas Müller,¹ Hagen Wende,¹ Katja Reuter,¹ Elena Vasyutina,¹ and Carmen Birchmeier¹

¹Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, 13125 Berlin, Germany, and ²Department of Human Anatomy and Psychobiology, University of Murcia, 30100 Murcia, Spain

Correspondence should be addressed to Carmen Birchmeier, Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Robert Rössle Strasse 10, 13125 Berlin, Germany. Email: cbirch{at}mdc-berlin.de

Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox gene Lbx1 is essential for imposing a somatosensory fate on relay neurons in the hindbrain. In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons.

Key words: neuronal specification; homeobox gene; nucleus of the solitary tract; spinal trigeminal nucleus; genetic lineage tracing; development

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Received May 11, 2005; revised March 8, 2007; accepted March 9, 2007.

Correspondence should be addressed to Carmen Birchmeier, Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Robert Rössle Strasse 10, 13125 Berlin, Germany. Email: cbirch{at}mdc-berlin.de

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