QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, May 23, 2007, 27(21):5621-5632; doi:10.1523/JNEUROSCI.4630-06.2007

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (25) Citing Articles via Google Scholar Google Scholar Articles by Balu, R. Articles by Strowbridge, B. W. Search for Related Content PubMed PubMed Citation Articles by Balu, R. Articles by Strowbridge, B. W.

 Previous Article  |  Next Article 

Cellular/Molecular
Multiple Modes of Synaptic Excitation of Olfactory Bulb Granule Cells

Ramani Balu, R. Todd Pressler, and Ben W. Strowbridge

Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106

Correspondence should be addressed to Dr. Ben W. Strowbridge, Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106. Email: bens{at}case.edu

Inhibition generated by granule cells, the most common GABAergic cell type in the olfactory bulb, plays a critical role in shaping the output of the olfactory bulb. However, relatively little is known about the synaptic mechanisms responsible for activating these interneurons in addition to the specialized dendrodendritic synapses located on distal dendrites. Using two-photon guided minimal stimulation in acute rat brain slices, we found that distal and proximal excitatory synapses onto granule cells are functionally distinct. Proximal synapses arise from piriform cortical neurons and facilitate with paired-pulse stimulation, whereas distal dendrodendritic synapses generate EPSCs with slower kinetics that depress with paired stimulation. Proximal cortical feedback inputs can relieve the tonic Mg block of NMDA receptors (NMDARs) at distal synapses and gate dendrodendritic inhibition onto mitral cells. Most excitatory synapses we examined onto granule cells activated both NMDARs and AMPA receptors, whereas a subpopulation appeared to be NMDAR silent. The convergence of two types of excitatory inputs onto GABAergic granule cells provides a novel mechanism for regulating the degree of interglomerular processing of sensory input in the olfactory bulb through piriform cortex/olfactory bulb synaptic interactions.

Key words: olfactory bulb; GABA; granule cell; mitral cell; synapse; piriform cortex; plasticity

---

Received Oct. 25, 2006; revised April 18, 2007; accepted April 19, 2007.

Correspondence should be addressed to Dr. Ben W. Strowbridge, Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106. Email: bens{at}case.edu

This article has been cited by other articles:

				J. H. Singer, E. Glowatzki, T. Moser, B. W. Strowbridge, V. Bhandawat, and A. P. Sampath Functional Properties of Synaptic Transmission in Primary Sense Organs J. Neurosci., October 14, 2009; 29(41): 12802 - 12806. [Abstract] [Full Text] [PDF]

				R. S. Smith, C. J. Weitz, and R. C. Araneda Excitatory Actions of Noradrenaline and Metabotropic Glutamate Receptor Activation in Granule Cells of the Accessory Olfactory Bulb J Neurophysiol, August 1, 2009; 102(2): 1103 - 1114. [Abstract] [Full Text] [PDF]

				H. Matsumoto, H. Kashiwadani, H. Nagao, A. Aiba, and K. Mori Odor-Induced Persistent Discharge of Mitral Cells in the Mouse Olfactory Bulb J Neurophysiol, April 1, 2009; 101(4): 1890 - 1900. [Abstract] [Full Text] [PDF]

				Z. Shao, A. C. Puche, E. Kiyokage, G. Szabo, and M. T. Shipley Two GABAergic Intraglomerular Circuits Differentially Regulate Tonic and Phasic Presynaptic Inhibition of Olfactory Nerve Terminals J Neurophysiol, April 1, 2009; 101(4): 1988 - 2001. [Abstract] [Full Text] [PDF]

				W. Kelsch, C.-W. Lin, and C. Lois Sequential development of synapses in dendritic domains during adult neurogenesis PNAS, October 28, 2008; 105(43): 16803 - 16808. [Abstract] [Full Text] [PDF]

				R. A. Fuentes, M. I. Aguilar, M. L. Aylwin, and P. E. Maldonado Neuronal Activity of Mitral-Tufted Cells in Awake Rats During Passive and Active Odorant Stimulation J Neurophysiol, July 1, 2008; 100(1): 422 - 430. [Abstract] [Full Text] [PDF]

				T. Inoue and B. W. Strowbridge Transient Activity Induces a Long-Lasting Increase in the Excitability of Olfactory Bulb Interneurons J Neurophysiol, January 1, 2008; 99(1): 187 - 199. [Abstract] [Full Text] [PDF]

				E. Chiang and B. W. Strowbridge Diversity of Neural Signals Mediated by Multiple, Burst-Firing Mechanisms in Rat Olfactory Tubercle Neurons J Neurophysiol, November 1, 2007; 98(5): 2716 - 2728. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help