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The Journal of Neuroscience, June 6, 2007, 27(23):6219-6223; doi:10.1523/JNEUROSCI.0851-07.2007

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Brief Communications
Selective Tuning of the Blood Oxygenation Level-Dependent Response during Simple Target Detection Dissociates Human Frontoparietal Subregions

Adam Hampshire, John Duncan, and Adrian M. Owen

MRC Cognition and Brain Sciences Unit, Cambridge, Cambridgeshire CB2 7EF, United Kingdom

Correspondence should be addressed to Dr. Adam Hampshire, MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, Cambridgeshire CB2 2EF, UK. Email: adam.hampshire{at}mrc-cbu.cam.ac.uk

Current models of working memory and focal attention converge on the idea of an adaptable global system, distributed across a network of frontal and parietal brain regions. Here, we examine how the human frontoparietal network selectively adapts to represent currently relevant information during a simple attentional task: monitoring for a target item in a series of nontargets. Across the entire frontoparietal network, there is selective response to targets, in line with a global system for coding task-relevant inputs. At the same time, there are striking dissociations in response to nontargets; whereas ventrolateral frontal cortex responds just to the target, more dorsal/anterior regions respond to all stimuli from the target category. The results show different degrees of target selectivity across different regions of the frontoparietal network.

Key words: attention; tuning; working memory; frontal cortex; parietal cortex; fMRI

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Received Oct. 31, 2006; revised March 27, 2007; accepted March 28, 2007.

Correspondence should be addressed to Dr. Adam Hampshire, MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, Cambridgeshire CB2 2EF, UK. Email: adam.hampshire{at}mrc-cbu.cam.ac.uk

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