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The Journal of Neuroscience, July 11, 2007, 27(28):7476-7481; doi:10.1523/JNEUROSCI.1083-07.2007

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Behavioral/Systems/Cognitive
Induction of Long-Term Memory by Exposure to Novelty Requires Protein Synthesis: Evidence for a Behavioral Tagging

Diego Moncada¹ and Haydée Viola^1,2

¹Instituto de Biología Celular y Neurociencias, Facultad de Medicina, and ²Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina

Correspondence should be addressed to Dr. Haydée Viola, Instituto de Biología Celular y Neurociencias, Paraguay 2155 3 piso, Facultad de Medicina, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina. Email: hviola{at}fmed.uba.ar

A behavioral analog of the synaptic tagging and capture process, a key property of synaptic plasticity, has been predicted recently. Here, we demonstrate that weak inhibitory avoidance training, which induces short- but not long-term memory (LTM), can be consolidated into LTM by an exploration to a novel, but not a familiar, environment occurring close in time to the training session. This memory-promoting effect caused by novelty depends on activation of dopamine D₁/D₅ receptors and requires newly synthesized proteins in the dorsal hippocampus. Thus, our results indicate the existence of a behavioral tagging process in which the exploration to a novel environment provides the plasticity-related proteins to stabilize the inhibitory avoidance memory trace.

Key words: inhibitory avoidance; spatial novelty; behavioral tag; hippocampus; long-term memory; rats

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Received Nov. 10, 2006; revised May 23, 2007; accepted May 30, 2007.

Correspondence should be addressed to Dr. Haydée Viola, Instituto de Biología Celular y Neurociencias, Paraguay 2155 3 piso, Facultad de Medicina, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina. Email: hviola{at}fmed.uba.ar

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Hunting for Synaptic Tagging and Capture in Memory Formation

José Viosca, Dragana Jancic, José P. López-Atalaya, and Eva Benito
J. Neurosci. 2007 27: 12761-12763. [Full Text]  

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