QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, July 11, 2007, 27(28):7553-7558; doi:10.1523/JNEUROSCI.1786-07.2007

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Poo, C. Articles by Isaacson, J. S. Search for Related Content PubMed PubMed Citation Articles by Poo, C. Articles by Isaacson, J. S.

 Previous Article  |  Next Article 

Brief Communications
An Early Critical Period for Long-Term Plasticity and Structural Modification of Sensory Synapses in Olfactory Cortex

Cindy Poo and Jeffry S. Isaacson

Department of Neuroscience, University of California, San Diego, School of Medicine, La Jolla, California 92093

Correspondence should be addressed to Dr. Jeffry S. Isaacson, Department of Neuroscience, MC 0634, Center for Molecular Genetics, Room 213, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0634. Email: jisaacson{at}ucsd.edu

Critical periods for plasticity of thalamic sensory inputs play an important role in developing neocortical circuits. During an early postnatal time window, pyramidal cells of visual, auditory, and somatosensory cortex undergo structural refinement and possess an enhanced ability for activity-dependent synaptic plasticity. In olfactory cortex, however, pyramidal cells receive direct sensory input from the olfactory bulb, and it is unclear whether the development of olfactory sensory circuits is governed by a critical period. Here, we show that NMDA receptor-dependent long-term potentiation and dendritic spine maturation occur only during a brief postnatal time window at sensory synapses of olfactory cortex pyramidal cells. In contrast, associational synapses onto the same cells retain the capacity for plasticity into adulthood.

Key words: piriform cortex; LTP; spines; LOT; olfaction; development

---

Received Feb. 12, 2007; revised June 7, 2007; accepted June 9, 2007.

Correspondence should be addressed to Dr. Jeffry S. Isaacson, Department of Neuroscience, MC 0634, Center for Molecular Genetics, Room 213, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0634. Email: jisaacson{at}ucsd.edu

This article has been cited by other articles:

				F. W. Johenning, P. S. Beed, T. Trimbuch, M. H. K. Bendels, J. Winterer, and D. Schmitz Dendritic Compartment and Neuronal Output Mode Determine Pathway-Specific Long-Term Potentiation in the Piriform Cortex J. Neurosci., October 28, 2009; 29(43): 13649 - 13661. [Abstract] [Full Text] [PDF]

				B. Bathellier, T. W. Margrie, and M. E. Larkum Properties of Piriform Cortex Pyramidal Cell Dendrites: Implications for Olfactory Circuit Design J. Neurosci., October 7, 2009; 29(40): 12641 - 12652. [Abstract] [Full Text] [PDF]

				Z. Zhou and L. Belluscio Intrabulbar Projecting External Tufted Cells Mediate a Timing-Based Mechanism That Dynamically Gates Olfactory Bulb Output J. Neurosci., October 1, 2008; 28(40): 9920 - 9928. [Abstract] [Full Text] [PDF]

				C. Abe, K. Tanaka, C. Awazu, and H. Morita Impairment of vestibular-mediated cardiovascular response and motor coordination in rats born and reared under hypergravity Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R173 - R180. [Abstract] [Full Text] [PDF]

				Y. Cohen, I. Reuveni, E. Barkai, and M. Maroun Olfactory Learning-Induced Long-Lasting Enhancement of Descending and Ascending Synaptic Transmission to the Piriform Cortex J. Neurosci., June 25, 2008; 28(26): 6664 - 6669. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help