QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, August 1, 2007, 27(31):8166-8169; doi:10.1523/JNEUROSCI.1556-07.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (16) Citing Articles via Google Scholar Google Scholar Articles by Murray, E. A. Articles by Schoenbaum, G. Search for Related Content PubMed PubMed Citation Articles by Murray, E. A. Articles by Schoenbaum, G.

 Previous Article  |  Next Article 

Mini-Review
What We Know and Do Not Know about the Functions of the Orbitofrontal Cortex after 20 Years of Cross-Species Studies

Elisabeth A. Murray,^1 * John P. O'Doherty,^2 * and Geoffrey Schoenbaum^3 *

¹Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, ²Computation and Neural Systems Program and Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, and ³Departments of Anatomy and Neurobiology and Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland 21201

Correspondence should be addressed to any of the following: Elisabeth A. Murray, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892, Email: murraye{at}mail.nih.gov; John P. O'Doherty, Computation and Neural Systems Program and Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, Email: jdoherty{at}caltech.edu; or Geoffrey Schoenbaum, Departments of Anatomy and Neurobiology and Psychiatry, University of Maryland School of Medicine, 20 Penn Street, HSF-2 S251, Baltimore, MD 21201, Email: schoenbg{at}schoenbaumlab.org

When Pat Goldman-Rakic described the circuitry and function of primate prefrontal cortex in her influential 1987 monograph (Goldman-Rakic, 1987), she included only a few short paragraphs on the orbitofrontal cortex (OFC). That year, there were only nine papers published containing the term "orbitofrontal," an average of less than one paper per month. Twenty years later, this rate has increased to 32 papers per month. This explosive growth is partly attributable to the remarkable similarities that exist in structure and function across species. These similarities suggest that OFC function can be usefully modeled in nonhuman and even nonprimate species. Here, we review some of these similarities.

Key words: conditioned; conditioning; human; learning; prefrontal cortex; primate; rat; reward

---

Received April 6, 2007; revised June 1, 2007; accepted June 4, 2007.

Correspondence should be addressed to any of the following: Elisabeth A. Murray, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892, Email: murraye{at}mail.nih.gov; John P. O'Doherty, Computation and Neural Systems Program and Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, Email: jdoherty{at}caltech.edu; or Geoffrey Schoenbaum, Departments of Anatomy and Neurobiology and Psychiatry, University of Maryland School of Medicine, 20 Penn Street, HSF-2 S251, Baltimore, MD 21201, Email: schoenbg{at}schoenbaumlab.org

This article has been cited by other articles:

				D. G. Ghahremani, J. Monterosso, J. D. Jentsch, R. M. Bilder, and R. A. Poldrack Neural Components Underlying Behavioral Flexibility in Human Reversal Learning Cereb Cortex, November 13, 2009; (2009) bhp247v1. [Abstract] [Full Text] [PDF]

				C. M. A. Pennartz, J. D. Berke, A. M. Graybiel, R. Ito, C. S. Lansink, M. van der Meer, A. D. Redish, K. S. Smith, and P. Voorn Corticostriatal Interactions during Learning, Memory Processing, and Decision Making J. Neurosci., October 14, 2009; 29(41): 12831 - 12838. [Abstract] [Full Text] [PDF]

				R. Elliott, Z. Agnew, and J.F.W. Deakin Hedonic and Informational Functions of the Human Orbitofrontal Cortex Cereb Cortex, May 12, 2009; (2009) bhp092v1. [Abstract] [Full Text] [PDF]

				S. A. De Brito, A. Mechelli, M. Wilke, K. R. Laurens, A. P. Jones, G. J. Barker, S. Hodgins, and E. Viding Size matters: Increased grey matter in boys with conduct problems and callous-unemotional traits Brain, April 1, 2009; 132(4): 843 - 852. [Abstract] [Full Text] [PDF]

				A. H. Lara, S. W. Kennerley, and J. D. Wallis Encoding of Gustatory Working Memory by Orbitofrontal Neurons J. Neurosci., January 21, 2009; 29(3): 765 - 774. [Abstract] [Full Text] [PDF]

				P. H. Rudebeck, T. E. Behrens, S. W. Kennerley, M. G. Baxter, M. J. Buckley, M. E. Walton, and M. F. S. Rushworth Frontal Cortex Subregions Play Distinct Roles in Choices between Actions and Stimuli J. Neurosci., December 17, 2008; 28(51): 13775 - 13785. [Abstract] [Full Text] [PDF]

				P. H. Rudebeck, D. M. Bannerman, and M. F. S. Rushworth The contribution of distinct subregions of the ventromedial frontal cortex to emotion, social behavior, and decision making Cogn Affect Behav Neurosci, December 1, 2008; 8(4): 485 - 497. [Abstract] [PDF]

				E. Z. Wheeler and L. K. Fellows The human ventromedial frontal lobe is critical for learning from negative feedback Brain, May 1, 2008; 131(5): 1323 - 1331. [Abstract] [Full Text] [PDF]

				H. Zheng and H.-R. Berthoud Neural Systems Controlling the Drive to Eat: Mind Versus Metabolism Physiology, April 1, 2008; 23(2): 75 - 83. [Abstract] [Full Text] [PDF]

				B. W. Balleine The Neural Basis of Choice and Decision Making J. Neurosci., August 1, 2007; 27(31): 8159 - 8160. [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help