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The Journal of Neuroscience, August 1, 2007, 27(31):8184-8189; doi:10.1523/JNEUROSCI.1685-07.2007

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Brief Communications
Cell Type-Specific Tuning of Hippocampal Interneuron Firing during Gamma Oscillations In Vivo

John J. Tukker,¹ Pablo Fuentealba,¹ Katja Hartwich,^1,2 Peter Somogyi,¹ and Thomas Klausberger^1,2

¹Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom, and ²Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria

Correspondence should be addressed to Dr. Thomas Klausberger, Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, UK. Email: thomas.klausberger{at}pharm.ox.ac.uk

Cortical gamma oscillations contribute to cognitive processing and are thought to be supported by perisomatic-innervating GABAergic interneurons. We performed extracellular recordings of identified interneurons in the hippocampal CA1 area of anesthetized rats, revealing that the firing patterns of five distinct interneuron types are differentially correlated to spontaneous gamma oscillations. The firing of bistratified cells, which target dendrites of pyramidal cells coaligned with the glutamatergic input from hippocampal area CA3, is strongly phase locked to field gamma oscillations. Parvalbumin-expressing basket, axo-axonic, and cholecystokinin-expressing interneurons exhibit moderate gamma modulation, whereas the spike timing of distal dendrite-innervating oriens-lacunosum moleculare interneurons is not correlated to field gamma oscillations. Cholecystokinin-expressing interneurons fire earliest in the gamma cycle, a finding that is consistent with their suggested function of thresholding individual pyramidal cells. Furthermore, we show that field gamma amplitude correlates with interneuronal spike-timing precision and firing rate. Overall, our recordings suggest that gamma synchronization in vivo is assisted by temporal- and domain-specific GABAergic inputs to pyramidal cells and is initiated in pyramidal cell dendrites in addition to somata and axon initial segments.

Key words: GABAergic interneurons; gamma oscillations; dendrites; hippocampus; juxtacellular recording; synchronization

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Received April 14, 2007; revised June 15, 2007; accepted June 17, 2007.

Correspondence should be addressed to Dr. Thomas Klausberger, Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Mansfield Road, Oxford OX1 3TH, UK. Email: thomas.klausberger{at}pharm.ox.ac.uk

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