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The Journal of Neuroscience, August 8, 2007, 27(32):8533-8545; doi:10.1523/JNEUROSCI.2106-07.2007

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Behavioral/Systems/Cognitive
Context Familiarity Enhances Target Processing by Inferior Temporal Cortex Neurons

Ryan E. B. Mruczek and David L. Sheinberg

Department of Neuroscience, Brown University, Providence, Rhode Island 02912

Correspondence should be addressed to David L. Sheinberg, Box G-L, Brown University, Sidney E. Frank Hall, 185 Meeting Street, Providence, RI 02912. Email: david_sheinberg{at}brown.edu

Experience-dependent changes in the response properties of ventral visual stream neurons are thought to underlie our ability to rapidly and efficiently recognize visual objects. How these neural changes are related to efficient visual processing during natural vision remains unclear. Here, we demonstrate a neurophysiological correlate of efficient visual search through highly familiar object arrays. Humans and monkeys are faster at locating the same target when it is surrounded by familiar compared with unfamiliar distractors. We show that this behavioral enhancement is driven by an increased sensitivity of target-selective neurons in inferior temporal cortex. This results from an increased "signal" for target representations and decreased "noise" from neighboring familiar distractors. These data highlight the dynamic properties of the inferior temporal cortex neurons and add to a growing body of evidence demonstrating how experience shapes neural processing in the ventral visual stream.

Key words: inferotemporal cortex; primate; object recognition; visual search; familiarity; neurophysiology

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Received May 8, 2007; revised June 15, 2007; accepted June 25, 2007.

Correspondence should be addressed to David L. Sheinberg, Box G-L, Brown University, Sidney E. Frank Hall, 185 Meeting Street, Providence, RI 02912. Email: david_sheinberg{at}brown.edu

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