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The Journal of Neuroscience, September 19, 2007, 27(38):10278-10288; doi:10.1523/JNEUROSCI.1602-07.2007

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Behavioral/Systems/Cognitive
Genetic Disruption of Protein Kinase A Anchoring Reveals a Role for Compartmentalized Kinase Signaling in Theta-Burst Long-Term Potentiation and Spatial Memory

Ting Nie,^1 * Conor B. McDonough,^1 * Ted Huang,^1 * Peter V. Nguyen,² and Ted Abel¹

¹Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, and ²Departments of Physiology and Psychiatry, Centre for Neuroscience, University of Alberta School of Medicine, Edmonton, Alberta, Canada T6G 2H7

Correspondence should be addressed to Ted Abel at the above address. Email: abele{at}sas.upenn.edu

Studies of hippocampal long-term potentiation (LTP), a cellular model of memory storage, implicate cAMP-dependent protein kinase (PKA) in presynaptic and postsynaptic mechanisms of LTP. The anchoring of PKA to AKAPs (A kinase-anchoring proteins) creates compartmentalized pools of PKA, but the roles of presynaptically and postsynaptically anchored forms of PKA in late-phase LTP are unclear. In this study, we have created genetically modified mice that conditionally express Ht31, an inhibitor of PKA anchoring, to probe the roles of anchored PKA in hippocampal LTP and spatial memory. Our findings show that at hippocampal Schaffer collateral CA3–CA1 synapses, theta-burst LTP requires presynaptically anchored PKA. In addition, a pool of anchored PKA in hippocampal area CA3 is required for spatial memory. These findings reveal a novel and significant role for anchored PKA signaling in cellular mechanisms underlying memory storage.

Key words: cAMP-dependent protein kinase; A kinase-anchoring proteins; hippocampus; spatial memory; synaptic plasticity; LTP

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Received April 10, 2007; revised Aug. 2, 2007; accepted Aug. 2, 2007.

Correspondence should be addressed to Ted Abel at the above address. Email: abele{at}sas.upenn.edu

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