QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, January 24, 2007, 27(4):818-823; doi:10.1523/JNEUROSCI.4706-06.2007

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Haghikia, A. Articles by Mittmann, T. Search for Related Content PubMed PubMed Citation Articles by Haghikia, A. Articles by Mittmann, T.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Long-Term Potentiation in the Visual Cortex Requires Both Nitric Oxide Receptor Guanylyl Cyclases

Arash Haghikia,^1 * Evanthia Mergia,^2 * Andreas Friebe,² Ulf T. Eysel,¹ Doris Koesling,² and Thomas Mittmann¹

¹Faculty of Medicine, Institute of Physiology, Department of Neurophysiology, and ²Faculty of Medicine, Institute of Pharmacology and Toxicology, Ruhr-University Bochum, D-44780 Bochum, Germany

Correspondence should be addressed to Doris Koesling, Faculty of Medicine, Institute of Pharmacology and Toxicology, Ruhr-University Bochum, D-44780 Bochum, Germany. Email: doris.koesling{at}ruhr-uni-bochum.de

The role of nitric oxide (NO)/cGMP signaling in long-term potentiation (LTP) has been a lingering matter of debate. Within the cascade, the NO receptor guanylyl cyclase (GC), the cGMP-forming enzyme that is stimulated by NO, plays a key role. Two isoforms of GC (₂-GC, ₁-GC) exist. To evaluate their contribution to synaptic plasticity, we analyzed knock-out mice lacking either one of the GC isoforms. We found that LTP induced in the visual cortex is NO dependent in the wild-type mice, absent in either of the GC isoform-deficient mice, and restored with application of a cGMP analog in both strains. The requirement of both NO receptor GCs for LTP indicates the existence of two distinct NO/cGMP-mediated pathways, which have to work in concert for expression of LTP.

Key words: LTP; visual cortex; NO; guanylyl cyclase; cGMP; KO

---

Received Oct. 30, 2006; revised Dec. 18, 2006; accepted Dec. 22, 2006.

Correspondence should be addressed to Doris Koesling, Faculty of Medicine, Institute of Pharmacology and Toxicology, Ruhr-University Bochum, D-44780 Bochum, Germany. Email: doris.koesling{at}ruhr-uni-bochum.de

This article has been cited by other articles:

				F. Taqatqeh, E. Mergia, A. Neitz, U. T. Eysel, D. Koesling, and T. Mittmann More than a Retrograde Messenger: Nitric Oxide Needs Two cGMP Pathways to Induce Hippocampal Long-Term Potentiation J. Neurosci., July 22, 2009; 29(29): 9344 - 9350. [Abstract] [Full Text] [PDF]

				H. Lin, C.-F. Cheng, H.-H. Hou, W.-S. Lian, Y.-C. Chao, Y.-Y. Ciou, B. Djoko, M.-T. Tsai, C.-J. Cheng, and R.-B. Yang Disruption of Guanylyl Cyclase-G Protects against Acute Renal Injury J. Am. Soc. Nephrol., February 1, 2008; 19(2): 339 - 348. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help