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The Journal of Neuroscience, October 31, 2007, 27(44):11966-11977; doi:10.1523/JNEUROSCI.3099-07.2007

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Behavioral/Systems/Cognitive
Processing of Odor Mixtures in the Drosophila Antennal Lobe Reveals both Global Inhibition and Glomerulus-Specific Interactions

Ana F. Silbering^1,2 and C. Giovanni Galizia²

¹Institute of Neurobiology, Free University of Berlin, 14195 Berlin, Germany, and ²Biology Department, University of Konstanz, 78457 Konstanz, Germany

Correspondence should be addressed to Dr. C. Giovanni Galizia, Lehrstuhl für Neurobiologie, Universität Konstanz, D-78457 Konstanz, Germany. Email: Giovanni.Galizia{at}uni-konstanz.de

To understand how odor information is represented and processed in the antennal lobe (AL) of Drosophila melanogaster, we have optically recorded glomerular calcium responses to single odors and odor mixtures from olfactory sensory neurons (OSNs) and projection neurons (PNs). Odor mixtures offer a good tool to analyze odor processing because experimental results can be tested against clear predictions. At the level of the OSNs, the representation of odor mixtures could be predicted from the response patterns of the components in most cases. PN responses to mixtures, however, provide evidences of interglomerular inhibition. Application of picrotoxin (PTX), an antagonist of GABA_A-like receptors, enhanced odor responses, modified their temporal course, and eliminated mixture suppression at the PN level. Our results can be best explained by postulating the existence of at least two local networks in the fly AL: a glomerulus specific network, which includes excitatory and inhibitory connections and a PTX sensitive inhibitory global network that acts on all glomeruli with proportional strength to the global AL input.

Key words: Drosophila melanogaster; olfaction; odor mixture; odor processing; antennal lobe; calcium imaging

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Received July 8, 2007; revised Sept. 14, 2007; accepted Sept. 16, 2007.

Correspondence should be addressed to Dr. C. Giovanni Galizia, Lehrstuhl für Neurobiologie, Universität Konstanz, D-78457 Konstanz, Germany. Email: Giovanni.Galizia{at}uni-konstanz.de

This article has been cited by other articles:

				J. A. Riffell, H. Lei, and J. G. Hildebrand Inaugural Article: Neural correlates of behavior in the moth Manduca sexta in response to complex odors PNAS, November 17, 2009; 106(46): 19219 - 19226. [Abstract] [Full Text] [PDF]

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