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The Journal of Neuroscience, November 7, 2007, 27(45):12132-12138; doi:10.1523/JNEUROSCI.2320-07.2007
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Behavioral/Systems/Cognitive
Human Motor Corpus Callosum: Topography, Somatotopy, and Link between Microstructure and Function
Mathias Wahl,1 Birgit Lauterbach-Soon,1 Elke Hattingen,2 Patrick Jung,1 Oliver Singer,1 Steffen Volz,3 Johannes C. Klein,1 Helmuth Steinmetz,1 andUlf Ziemann1 1Department of Neurology, 2Institute of Neuroradiology, and 3Brain Imaging Center, Johann Wolfgang Goethe-University of Frankfurt, D-60528 Frankfurt am Main, Germany
Correspondence should be addressed to Prof. Ulf Ziemann, Motor Cortex Group, Department of Neurology, Johann Wolfgang Goethe-University of Frankfurt, Schleusenweg 2-16, D-60528 Frankfurt am Main, Germany. Email: u.ziemann{at}em.uni-frankfurt.de
The corpus callosum (CC) is the principal white matter fiber bundle connecting neocortical areas of the two hemispheres. Although an object of extensive research, important details about the anatomical and functional organization of the human CC are still largely unknown. Here we focused on the callosal motor fibers (CMFs) that connect the primary motor cortices (M1) of the two hemispheres. Topography and somatotopy of CMFs were explored by using a combined functional magnetic resonance imaging/diffusion tensor imaging fiber-tracking procedure. CMF microstructure was assessed by fractional anisotropy (FA), and CMF functional connectivity between the hand areas of M1 was measured by interhemispheric inhibition using paired-pulse transcranial magnetic stimulation. CMFs mapped onto the posterior body and isthmus of the CC, with hand CMFs running significantly more anteriorly and ventrally than foot CMFs. FA of the hand CMFs but not FA of the foot CMFs correlated linearly with interhemispheric inhibition between the M1 hand areas. Findings demonstrate that CMFs connecting defined body representations of M1 map onto a circumscribed region in the CC in a somatotopically organized manner. The significant and topographically specific positive correlation between FA and interhemispheric inhibition strongly suggests that microstructure can be directly linked to functional connectivity. This provides a novel way of exploring human brain function that may allow prediction of functional connectivity from variability of microstructure in healthy individuals, and potentially, abnormality of functional connectivity in neurological or psychiatric patients.
Key words: motor corpus callosum; diffusion tensor imaging; fractional anisotropy; microstructure; transcranial magnetic stimulation; interhemispheric inhibition; functional connectivity
Received May 21, 2007; revised Sept. 4, 2007; accepted Sept. 5, 2007.
Correspondence should be addressed to Prof. Ulf Ziemann, Motor Cortex Group, Department of Neurology, Johann Wolfgang Goethe-University of Frankfurt, Schleusenweg 2-16, D-60528 Frankfurt am Main, Germany. Email: u.ziemann{at}em.uni-frankfurt.de
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