QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 7, 2007, 27(45):12176-12189; doi:10.1523/JNEUROSCI.3761-07.2007

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Johnson, A. Articles by Redish, A. D. Search for Related Content PubMed PubMed Citation Articles by Johnson, A. Articles by Redish, A. D.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Neural Ensembles in CA3 Transiently Encode Paths Forward of the Animal at a Decision Point

Adam Johnson¹ and A. David Redish²

¹Center for Cognitive Sciences and ²Department of Neuroscience, Univeristy of Minnesota, Minneapolis, Minnesota 55455

Correspondence should be addressed to A. David Redish, Department of Neuroscience, Univeristy of Minnesota, 6-145 Jackson Hall, 321 Church St. Southeast Minneapolis, MN 55455. Email: redish{at}ahc.umn.edu

Neural ensembles were recorded from the CA3 region of rats running on T-based decision tasks. Examination of neural representations of space at fast time scales revealed a transient but repeatable phenomenon as rats made a decision: the location reconstructed from the neural ensemble swept forward, first down one path and then the other. Estimated representations were coherent and preferentially swept ahead of the animal rather than behind the animal, implying it represented future possibilities rather than recently traveled paths. Similar phenomena occurred at other important decisions (such as in recovery from an error). Local field potentials from these sites contained pronounced theta and gamma frequencies, but no sharp wave frequencies. Forward-shifted spatial representations were influenced by task demands and experience. These data suggest that the hippocampus does not represent space as a passive computation, but rather that hippocampal spatial processing is an active process likely regulated by cognitive mechanisms.

Key words: hippocampus; place cell; neural ensemble; vicarious trial; visual error; decision making; cognition

---

Received June 19, 2007; revised Sept. 12, 2007; accepted Sept. 18, 2007.

Correspondence should be addressed to A. David Redish, Department of Neuroscience, Univeristy of Minnesota, 6-145 Jackson Hall, 321 Church St. Southeast Minneapolis, MN 55455. Email: redish{at}ahc.umn.edu

This article has been cited by other articles:

				J. Lisman and G. Buzsaki A Neural Coding Scheme Formed by the Combined Function of Gamma and Theta Oscillations Schizophr Bull, September 1, 2008; 34(5): 974 - 980. [Abstract] [Full Text] [PDF]

				M. M. Yartsev Dissociating the Effects of Past and Future on Neural Encoding of Sequences in The Hippocampus J. Neurosci., August 20, 2008; 28(34): 8383 - 8384. [Full Text] [PDF]

				R. L. BUCKNER, J. R. ANDREWS-HANNA, and D. L. SCHACTER The Brain's Default Network: Anatomy, Function, and Relevance to Disease Ann. N.Y. Acad. Sci., March 1, 2008; 1124(1): 1 - 38. [Abstract] [Full Text] [PDF]

				D. L. SCHACTER, D. R. ADDIS, and R. L. BUCKNER Episodic Simulation of Future Events: Concepts, Data, and Applications Ann. N.Y. Acad. Sci., March 1, 2008; 1124(1): 39 - 60. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help