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The Journal of Neuroscience, November 7, 2007, 27(45):12331-12340; doi:10.1523/JNEUROSCI.1358-07.2007

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Cellular/Molecular
Prion Protein Regulates Glutamate-Dependent Lactate Transport of Astrocytes

Ralf Kleene,¹ Gabriele Loers,¹ Julia Langer,¹ Yveline Frobert,³ Friedrich Buck,² and Melitta Schachner^1,4

¹Zentrum für Molekulare Neurobiologie and ²Institut für Zellbiochemie und Klinische Neurobiologie, Universität Hamburg, 20246 Hamburg, Germany, ³Commissariat à l'Energie Atomique, Service de Pharmacologie et d'Immunologie, 91191 Gif-sur-Yvette Cedex, France, and ⁴Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, New Jersey 08854

Correspondence should be addressed to Melitta Schachner, Zentrum für Molekulare Neurobiologie, Universität Hamburg, Martinistrasse 52, D-20246 Hamburg, Germany. Email: melitta.schachner{at}zmnh.uni-hamburg.de

Prion-related protein (PrP) is a neural cell adhesion molecule involved in neurite outgrowth, neuronal survival, and synaptic function. In search of novel binding partners for PrP, we identified the 2/ß2-Na⁺/K⁺-ATPase and showed that this astroglial ATPase interacts directly with the immunoglobulin superfamily adhesion molecule basigin. In cultured astrocytes, PrP is involved in regulating lactate transport via the astroglial monocarboxylate transporter 1 (MCT1) and in conjunction with 2/ß2-ATPase and basigin. Lactate transport via MCT1 is glutamate dependent and regulated by glutamate receptor 2 (GluR2)-containing AMPA receptors with which PrP interacts. The functional interplay between PrP, GluR2, 2/ß2-ATPase, basigin, and MCT1 in regulating lactate transport of astrocytes may be functional in the metabolic cross talk between astrocytes and neurons, most likely under stress.

Key words: prion protein; astrocytes; Na⁺/K⁺-ATPase; AMPA receptor; basigin; lactate transport

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Received March 27, 2007; revised July 19, 2007; accepted Aug. 1, 2007.

Correspondence should be addressed to Melitta Schachner, Zentrum für Molekulare Neurobiologie, Universität Hamburg, Martinistrasse 52, D-20246 Hamburg, Germany. Email: melitta.schachner{at}zmnh.uni-hamburg.de

This article has been cited by other articles:

				A. Lieberoth, F. Splittstoesser, N. Katagihallimath, I. Jakovcevski, G. Loers, B. Ranscht, D. Karagogeos, M. Schachner, and R. Kleene Lewisx and {alpha}2,3-Sialyl Glycans and Their Receptors TAG-1, Contactin, and L1 Mediate CD24-Dependent Neurite Outgrowth J. Neurosci., May 20, 2009; 29(20): 6677 - 6690. [Abstract] [Full Text] [PDF]

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